Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia
スポンサーリンク
概要
- 論文の詳細を見る
It is important to improve the efficacy of surveillance in UC patients with neoplasia.In the present study, we assessed the cut-off value of expression of DNMT-1 and DNMT-3b expressionin the non-neoplastic rectal epithelium of patients with long-standing and extensive UC. Sixty patients withlong-standing and extensive UC paticipated in this study( 30 with colorectal neoplasia and 30 without). Immunohistochemicalanalysis was performed to determine the expression of DNMT-1 and 3b in non-neoplasticrectal epithelium of UC patients without neoplasia, and in non-neoplastic rectal epithelium of UC patientswith neoplasia. The level of immunoreactive DNMT-1 and DNMT-3b expression was determined as thepercentage of positive cells relative to the total number of cells counted under high power magnification.DNMT-1 and 3b expression in non-neoplastic rectal epithelium of UC patients with neoplasia (0.57, range0.53-0.63)(0.32, range 0.18-0.67) was higher than in the non-neoplastic epithelium of UC patients withoutneoplasia (0.41, range 0.25-0.54, P=.001)(0.0, range 0.0-0.13, P<.001). ROC curve analysis confirmed0.53 and 0.07 as the best DNMT-1 and DNMT-3b cut-off values for identifying individuals at increasedrisk of neoplasia( area under the curve=0.798 and 0.842, respectively). The cut-off value for DNMT-1 andDNMT-3b expression in non-neoplastic rectal epithelium is therefore an efficient predictor for the increasedrisk of UC-associated neoplasia.
- 獨協医科大学の論文
- 2012-03-25
著者
-
Yasuda Yoshikazu
Department Of Anesthesiology And Reanimatology Fukui Medical University
-
Ichikawa Kazuhito
Department Of Surgery Kyowa Central Hospital
-
Fujimori Takahiro
Department Of Geriatric Medicine Osaka University Graduate School Of Medicina
-
Tanaka Hiroyuki
Department Of Anesthesia And Clinical Research Institute National Hospital Organization Kyushu Medic
-
Shinichiro Ohtake1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine1
-
Hiroyuki Tanaka1
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine1, Depar
-
Kazuhito Ichikawa1
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine1
-
Takahiro Fujimori1
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine1
-
Yoshikazu Yasuda2
Department of Surgery, Jichi Medical University School of Medicine2
-
Hiroyuki Tanaka1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine1 Departm
-
Yoshikazu Yasuda2
Department Of Surgery Jichi Medical University School Of Medicine2
-
Kazuhito Ichikawa1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine1
-
Takahiro Fujimori1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine1
-
Takahiro Fujimori1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine Tochigi
-
Kazuhito Ichikawa1
Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine Tochigi Japan1
-
Yasuda Yoshikazu
Department of Surgery, Jichi Medical University School of Medicine
-
Ichikawa Kazuhito
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
-
Tanaka Hiroyuki
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Department of Surgery, Jichi Medical University School of Medicine
-
Ohtake Shinichiro
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
関連論文
- Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53
- Successful Treatment of Primary Cardiac Lymphoma With Atrioventricular Nodal Block
- PJ-762 The Ratio and Lesion Morphology of Recurrent Restenosis after Reimplantation with Sirolimus-eluting Stent for Restenosis after Sirolimus-eluting Stent Implantation(PJ128,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (Japanese),The 73
- PJ-478 The Detection of Cancer with Multidetecter Computed Tomography Coronary Angiography(PJ081,CT/MRI (Coronary/Vascular) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-408 Sirolimus-eluting Stent Implantation for In-stent Restenosis of Bare Metal Stent or Sirolimus-eluting Stent(PJ069,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
- PE-379 Late Restenosis of Sirolimus Eluting Stent Implantation in Chronic Total Occlusions(PE064,Coronary Revascularization, PCI (DES) 6 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-280 Unique Distribution of Stent Fracture and Stent Fracture with Restenosis after Sirolimus-Eluting Stent Implantation(PE047,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circ
- PE-134 Is Previous Angiography as Follow up Useful to Predict Very Late Stent Thrombosis?(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-255 Usefulness of Stress Myocardial Perfusion Imaging (MPI) in Detecting Significant Coronary Artery Stenosis in Multidetector Row Computed Tomography (MDCT) Era(OJ43,Nuclear Cardiology (Coronary, Myocardium) (I),Oral Presentation (Japanese),The 73rd A
- OJ-121 Predictors of Recurrent Restenosis after Treatment of Bifurcation Lesions with the Two-stent Strategy(OJ21,Coronary Revascularization, PCI (Complex Lesions) 2 (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
- OE-403 Stent Fracture and Stent Thrombosis after Sirolimus-eluting Stent Implantation(OE68,Coronary Revascularization, PCI (Restenosis/Others) 4 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-188 Prevalence and Predictors of Early and Late Restenosis after Sirolimus-Eluting Stent Implantation for de novo Lesion(OE32,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- PJ-657 Optimal Strategy of Restenosis with Stent Fracture after Sirolimus-eluting stent Implantation(Coronary revascularization, PCI(24)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-258 The 2-year Follow-up Results of Drug Eluting Stent Implantation for the de novo Unprotected Left Main Coronary Artery Disease.(Coronary revascularization, PCI(19)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-049 The Long-Term Predictors of Restenosis and Target-Lesion-Revascularization after Drug-Eluting-Stent Implantation for the de novo Unprotected Left Main Coronary Artery Disease.(Coronary revascularization, PCI(07)(IHD),Poster Session(English),The 72n
- OE-004 Late Restenosis After Sirolimus-eluting Stent Implantation : The Impact of Lesion Complexity(Coronary revascularization, PCI(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-025 Middle-term angiographic follow-up of BioMatrix^ stent implantation for left main to left anterior descending artery(Forefront Updates in PCI(01)(IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-744 Long-term Outcome of Treatment of De Novo Right Coronary Artery Ostial Lesions, Comparison with Drug-eluting Stents and Bare Metal Stents(Coronary revascularization, PCI-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-601 Prevalence of Side Effects of Clopidgrel Which was Prescribed to the Patients who Discontinued Ticlopidine due to its Side Effects(Coronary revascularization, PCI-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-266 The Angiographical Findings of the Late Restenosis : Comparison Between SES AND BMS Lesions(Restenosis basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Development of an Enzyme Linked Immunosorbent Assay for Direct Determination of Anticancer Drug Vitamin K3 in Serum
- Localization of Stem Cells in Small Intestinal Epithelium:Strategies for Identifying Small Intestinal Stem Cells
- Improved Stability of Metal-Insulator-Diamond Semiconductor Interface by Employing BaF_2 Insulator Film
- THE STUDY OF HYPERTROPHIED RAT HEART : 1. THE NEW METHOD TO MAKE HYPERTROPHIED RAT HEART : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- DHPLCを用いた日本人骨形成不全症(OI)におけるI型コラーゲンの遺伝子解析
- Lactobacillus Acidophilus Strain L-92 Regulates the Production of Th1 Cytokine as well as Th2 Cytokines
- Production of Matrix Metalloproteinases in Human Cultured Mast Cells : Involvement of Protein Kinase C-Mitogen Activated Protein Kinase Kinase-Extracellular Signal-regulated Kinase Pathway
- Establishment of Allergic Dermatitis in NC/Nga Mice as a Model for Severe Atopic Dermatitis(Pharmacology)
- The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
- Gastrointestinal stromal tumor of the stomach with extremely slow-growing hematogenous metastasis
- Negative immunohistochemical staining of p53 protein does not always reflect wild-type p53 gene in cancer cells
- Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line, T.Tn-AT1, by cDNA microarray
- Intitial transformed cells of colorectal adenoma : do they occur at the top of the crypt?
- Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors
- HISTO-IN SITU HYBRIDIZATION USING IN VIVO METABOLICALLY-LABELED BROMODEOXYURIDINE DNA PROBES AND APPLICATION TRIAL FOR PATHOLOGICAL DIAGNOSIS (In situ Hybridization III. : Application for Medical Investigation)
- Genetic analysis of a local recurrent tumor after colonic polypectomy
- Immunohistochemical expression of cyclooxygenase (COX)-2 in colorectal adenomas
- Depth of Tumor Invasion in Locally Advanced Rectal Cancer Correlates with Patients' Prognosis : The Usefulness of Elastic Stain for Its Measurement
- A MULTICENTER RANDOMIZED CONTROLLED TRIAL DESIGNED TO EVALUATE FOLLOW-UP SURVEILLANCE STRATEGIES FOR COLORECTAL CANCER : THE JAPAN POLYP STUDY
- Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma : a Japanese collaborative study
- Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal cancer : Possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1
- Short-segment Barrett's esophagus associated with high-grade dysplasia
- Biliary Papillomatosis Arising in a Congenital Choledochal Cyst : Report of a Case
- Barrett's esophagus
- Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma
- Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors
- Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer
- Genetic changes in colorectal adenoma and cancer in relation to various morphologic aspects
- Efficacy of surveillance and molecular markers for detection of ulcerative colitis-associated colorectal neoplasia
- A case of primary esophageal tuberculosis diagnosed by identification of Mycobacteria in paraffin-embedded esophageal biopsy specimens by polymerase chain reaction
- How does adenosquamous carcinoma arise in the small intestine?
- Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma
- The feasibility of an animal laboratory for teaching surgical techniques to medical students : Teaching in a non-clinical environment
- HP-167-4 Positive impact of a patient-based short-term intervention for English language teaching in surgery
- Effect of Intraperitoneal Neutrophils Induced by OK432 on Malignant Ascites
- Management of complications after Partial hepatic resection in a hemodialysis patient with severe hepatomegaly caused by autosomal dominant polycystic kidney disease
- Preoperative Cardiac Evaluation : When Should the Surgeon Consult the Cardiologist?
- T-tube drainage stimulates the healing of choledocho-choledochostomies : An experimental study in pigs
- Reconstruction of the common bile duct by a vascular prosthetic graft : an experimental study in pigs
- Idiopathic extensive peliosis hepatis treated with liver transplantation
- Prevalence of Synchronous Colorectal Neoplasms Detected by Colonoscopy in Patients with Gastric Cancer
- Pathological Predictors for Lymph Node Metastasis in T1 Colorectal Cancer
- Limitations of three-dimensional intraductal ultrasonography in the assessment of longitudinal spread of extrahepatic bile duct carcinoma
- Calcium Antagonist Inhibits Glomerular Cell Apoptosis and Injuries of L-NAME Exacerbated Nephrosclerosis in SHR
- Gastrointestinal reflux disease and cell cycle-regulating proteins
- Clinicopathologic evaluation of the trend toward histologically poor differentiation with submucosal invasion in superficial early colorectal adenocarcinomas
- FORMATION OF GASTROCOLIC FISTULA DURING TREATMENT FOR PEPTIC ULCER
- Telomerase activity and human telomerase RNA component in gastrointestinal diseases
- Alternate-day treatment with S-1 in patients with gastric cancer : a retrospective study of strategies for reducing toxicity
- Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer
- Comparison of alternate-day versus consecutive-day treatment with S-1 : assessment of tumor growth inhibition and toxicity reduction in gastric cancer cell lines in vitro and in vivo
- Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1
- Alternate-day oral therapy with TS-1 for advanced gastric cancer
- The early influence of albumin administration on protein metabolism and wound healing in burned rats
- Ulcerative colitis-associated neoplasia
- Evaluation of a new scoring system for primary biliary cirrhosis and its related variant forms
- Precancerous lesions of the colorectum
- Sclerosing variant of epithelioid angiomyolipoma
- Immunohistochemical study of characteristics of bile duct dysplasia evaluated on the basis of expression of metastasis/invasion-related factors and p53
- Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer : a Japanese collaborative study
- Relation with Preoperative Fructosamine and Autonomic Nerve Function and Blood Pressure during Anesthesia in Diabetics : A Retrospective Study
- Ectopic Gastric Mucosa and Pancreatic Ducts in the Rectum
- Pancreatic bladder or double gallbladder draining into pancreatic duct?
- Multiple carcinoid tumors of the gallbladder and cystic duct
- Transintestinal hepatectomy performed by hybrid NOTES using a customized X-TRACT Tissue Morcellator with an electrifiable round cutter
- Introduction of the General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus:Evaluation of invasion distance and budding appearance in early colorectal cancer
- A gallbladder flap for reconstruction of the common bile duct. An experimental study on pigs
- VIRTUAL ENTEROSCOPY USING AIR AS THE CONTRAST MATERIAL : A PRELIMINARY FEASIBILITY STUDY
- Experimental evaluation of portal venous pulsatile flow synchronized with heartbeat intervals
- Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia
- A Novel Approach to Endoscopic Submucosal Dissection Using Bipolar Current Needle Knife for Colorectal Tumors
- Risk of lymph node metastasis in patients with pedunculated type early invasive colorectal cancer : A retrospective multicenter study
- Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
- Floating gallbladder strangulation caused by the lesser omentum : report of a case
- IgG4-positive Plasmocytosis of Inflammatory Cell Spreading Pattern Revealed to Differentiation in Classic Oral Lichen Planus
- Validation of Pyrosequencing for the Analysis of KRAS Mutations in Colorectal Cancer
- Intestinal strangulation caused by a mucocele of the appendix : report of a case
- Partial duplication of MSH2 spanning exons 7 through 14 in Lynch syndrome
- Acquired hemophilia A caused by factor VIII inhibitors : report of a case