脳動脈瘤初期病変における血行力学の役割(生体の流れ(2),一般講演)

概要

論文の詳細を見る
A cerebral aneurysm is a bulge in a segment of the cerebral artery, its rupture followed by subarachnoid hemorrhage is a serious disease with high mortality and morbidity. The pathogenesis of cerebral aneurysms is still unclear although various studies based for hemodynamics, immunohistochemistry and genetics to solve it. The purpose of this study is to clarify the relationship between wall shear stress (WSS) and its spatial gradient (WSSG) caused by blood flow and the degenerative changes in arterial wall tissues followed by formation of cerebral aneurysms. We used models of rat cerebral bifurcation with an experimentally induced aneurysm to estimate the WSS on it. WSS and WSSG distribution are calculated with CFD method and PIV experimentation. In contrast, thickness of arterial wall tissues, especially internal elastic lamina (IEL) and medial smooth muscle cells (SMCs), were measured with light-microscopic pictures of stained vessel tissues.
日本流体力学会の論文
2010-09-09