3J5-4 NIPAゲル流路を用いたソノポレーションの評価(医用超音波)

概要

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It is considered that sonopolation, which makes small pores through cell membrane, may be a sophisticated method in order to improve efficacy in ultrasonic wave irradiated drug delivery system. However, neither precise mechanism of sonoporation nor optimum sequence of insonation has been clarified. In this paper, effects of pre-trapping of micro bubbles to the target wall, which is carried out by pumping ultrasonic wave before insonation using high intensity ultrasonic wave, is evaluated by N-isopropylacrylamide (NIPA) gel flow channel. Both amount of trapped bubbles on the wall during pre-trapping and density of micro hollows on the wall after insonation using high intensity ultrasonic wave are evaluated simultaneously.
超音波エレクトロニクスの基礎と応用に関するシンポジウム運営委員会の論文
2009-11-18