インスリン非依存型糖尿病の分子遺伝学(遺伝医学の最近の進歩,シンポジウム)

概要

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Diabetes mellitus is a heterogeneous disease characterized with a disorder of glucose metabolism which lead to the chronic hyperglycemia. Both genetic and environmental factors contribute to the development of this disorder. Therefore, genes which are responsible for the development of both IDDM and NIDDM have been studying to date. The strategy to study diabetes-susceptibility genes included (1) population association study, (2) direct screening, (3) linkage analysis and (4) animal model. Recently, multiple susceptible loci for developing IDDM have been successfully identified by genome-wide screen. In the NIDDM field, it has shown that the mutations in the hepatocyte nuclear factor (HNF)-1α and 4α genes are the causes of maturity-onset diabetes of the young 3 (MODY3) and MODY1, respectively. In addition, susceptible loci for common late-onset NIDDM have heen identified designated as NIDDM1 and NIDDM2. Most of all these findings were based on the linkage analysis which has a strong power to detect the disease susceptible loci regardless of the information of the target gene. Here I am going to introduce the brief summary how the diabetes genes have been studying including up dated information of this field.
東京女子医科大学の論文
1998-05-25