熱性けいれんに及ぼすテオフィリンの影響の研究

概要

論文の詳細を見る
We studied the effects of theophylline on febrile seizures (FS) in children. A total of 278 patients who had 504 episodes of FS were evaluated. Of these, 32 patients had 62 episodes of FS while receiving theophylline. There were no differences between patients with and without theophylline treatment in the sex ratio, average age at each episode of FS, family history of FS or underlying developmental problems. Seizures were on average 10 minutes longer in patients receiving theophylline than in control patients, and were atypical. Significantly more patients with FS while receiving theophylline had abnormal neurological histories. More than 75% of the patients on theophylline had been receiving this drug for more than one month prior to their seizure. The serum concentrations of theophylline obtained immediately after the seizure episode were all under 15μg/ml, and 78.5% were under 10μg/ml. These results suggest that atypical FS with theophylline treatment might be induced by this treatment, and that children with prior neurological dysfunction may be at risk of theophylline induced FS.
東京女子医科大学の論文
1999-11-25