糖尿病妊婦と酸化ストレス(糖尿病と活性酸素,東京女子医科大学学会第316回例会)

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In offspring of diabetic mothers congenital malformations are common if blood glucose is poorly controlled during the period of organogenesis. Studies of embryos in culture have suggested that an enhanced production of free radicals is related to the risk of congenital malformations. To clarify the cause of malformations in infants of diabetic mothers, we investigated the maternal plasma phosphatidylcholine hydroperoxide (PCOOH) levels, as an index of oxidative stress. In the first trimester there were no differences in plasma PCOOH levels in diabetic pregnant women when compared to normal pregnant women and to healthy non-pregnant women. None of the infants born from the diabetic mothers had malformations. We were unable to find any relation between maternal PCOOH levels and malformations in infants of diabetic mothers. Administration of vitamine E, a liposoluble free radical scavenger, to diabetic animals has been reported to reduce congenital malformations. We investigated the changes of α-tocopherol, the main component of vitamine E, in pregnancy to elucidate the correlation between fetal anomaly and plasma α-tocopherol levels in diabetic pregnant women. No difference in plasma α-tocopherol level was found in diabetic pregnant women when compared to normal pregnant women. Two diabetic pregnant women delivered neonates with cardiovascular defects, but the maternal plasma α-tocopherol levels were within the normal range in the first trimester which is an important period of organogenesis.
1999-05-25

糖尿病妊婦と酸化ストレス(糖尿病と活性酸素,東京女子医科大学学会第316回例会)

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