米ぬか水抽出物のペルオキシナイトライト消去能

概要

論文の詳細を見る
Oxidative stress is known as one of the major causes of diseases and is known to be initiated by reactive oxygen species(ROS).Peroxynitrite(PON)is a highly reactive ROS, which can nitrate and oxidize biomolecules, and is produced by the rapid reaction between superoxide and nitric oxide. In tissues of patients with a number of diseases, 3-nitrotyrosine has been detected. These results strongly suggest that there is formation of PON in the tissues in vivo. Therefore, from the standpoint of preventive medicine, it is important to clarify the PON scavenging activities of dietary antioxidants. In this study, we used three methods to evaluate the efficacy of rice bran to protect proteins from peroxynitrite-mediated modification. By coexistence of the rice bran extract in the reaction mixture, inhibition of pig heart lactate dehydrogenase by 1mM PON treatment was suppressed about 70%, and the formation of 3-nitrotyrosine and yellow pigment production by 1mM PON in bovine serum albumin were inhibited about 75% and 60%, respectively. These results suggest that there is strong scavenging activity of PON in the extract of rice bran.
昭和女子大学の論文
2009-12-01