One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

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概要

• 論文の詳細を見る

• Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B.

• 公益社団法人日本生物工学会の論文

著者

• Tsuchida Toshio

  Bioresource Laboratories Mercian Corp.

• MACHIDA Kazuhiro

  Bioresource Laboratories, Mercian Corp.

• Aritoku Yasuhide

  Bioresource Laboratories Mercian Corp.

• Machida Kazuhiro

  Bioresource Laboratories Mercian Corp.

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• One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

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