胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第1編 胃位相ニヨル影響
スポンサーリンク
概要
- 論文の詳細を見る
It is a well established fact that the secretagogues present in food or resulting from the digestion of food stimulate gastric secretion on being applied directly to the gastric mucosa, but no one has determined whether they contain substances such as histamine, histamine-like substances or vasodepressor substances. Also it is not known whether secretagogues act on gastric glands only after absorption or not, or for how long, or what is the quantitative response of the gastric glands to the secretagogues. In an attempt to throw some light on the above problem the author used dogs with entire stomach pouches and duodeno-esophageal anastomosis and sectioned the vagi. Liver extract No. 343 prepared by Eli Lilly & Co. and Liebigs meat extract were selected as the experimental substances. These substances were found to contain a cansiderable amount of a vasodepressor substance, which was removed by Lloyd's reagent. The original extract and the extract after treatment with Lloyd's reagent were applied to the entire stomach pouch as described above. 2.1gm of liver extract (representing 50gm of fresh liver), dissolved in 50cc of water and 5gm of meat extract, also in 50cc water, were applied at different times for 30min. for the purpose of comparing the secretagogue value of these materials. 4.2gm of the original extract dissolved in 50cc of water was applied at four different 30min. periods at certain intervals to test whether the action of the secretagogues on gastric secretion is influenced by absorption or not. Fresh solution of liver extract was applied for 30, 60, 90 and 120min. respectively to test how long the action was maintained and what was the comparative quantitative result. In another experiment 2mg. of atropine sulphate was injected subcutaneously one hour before the application of the vasodepressor-free extract to the gastric mucosa in order to determine the action of atropine on gastric secretion after local chemical stimulation. All these experiments were performed on animals when the intestinal phase of gastric secretion was not manifest. The conclusions from these experiments are as follows: 1) Vasodepressor-containing and vasodepressor-free liver and meat extract have approximately the same stimulating action on gastric secretion when applied directly to the stomach mucosa. Therefore, the presence of small quantities of a vasodepressor substance in a secretagogue preparation does not enhance its action on the stomach. 2) Secretagogues on being applied to the gastric mucosa do not stimulate as a result of absorption. They act by stimulating the formation of a hormone or by a local nervous mechanism, or both. 3) Secretagogues in the stomach show an accumulative stimulating effect up to a certain maximum period of time. 4) Atropine inhibits this local action of vasodepressor-free secretagogues.
- 京都府立医科大学の論文
著者
関連論文
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響(學位論文審査要旨)
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第1編 胃位相ニヨル影響
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第2編 腸位相ニヨル影響
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第3編 Pavlov瘻犬ニ於ケル經口投與ノ影響
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第4編 非經口的投與ニヨル影響
- 胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第5編 胃液分泌ニ及ボス幽門部ノ役割