胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第2編腸位相ニヨル影響

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It is well known that the introduction into the intestine of a solution containing secretagogues causes stimulation of gastric secretion. But no one has ever observed the effect on gastric secretion of vasodepressor-free substances introduced into the intestine. Nor is the mechanism of this understood. In this study I tried to elucidate the mechanism of gastric secretion during the intestinal phase as well as to compare the action of ordinary commercial liver extract in stimulating gastric secretion during the intestinal phase with the action of vasodepressor-free substances under the same conditions. Two types of dog were used in this experiment. The one had a whole stomach pouch as mentioned earlier in this paper, and the other was a Thiry fistula dog (jejunal loop about 15 inches long) with gastrostomy. Liver extract No. 343 was again selected as the standard substance and the vasodepressor substance was removed as previously mentioned. One vial containing 4.2gm. of liver extract representing 100gm. of fresh liver, was dissolved in 30cc. of water and given by mouth to the entire stomach pouch dogs, the substance passing directly into the intestine; and the same quantity was introduced into the Thiry fistula of the Thiry fistula dogs above mentioned. In the case of the Thiry fistula, the substance introduced was withdrawn after intervals of 30, 60, 90, 120min. respectively and the action of the secretagogue was observed in so far as it was absorbed by the intestine or not. All these experiments were, performed when there was no activity due to the intestinal phase of gastric secretion in whole stomach pouch dogs and no activity from either the gastric or the intestinal phase in Thiry fistula dogs with gastrostomy. The final results of these experiments are as follows: 1) The original liver extract was more effective than vasodepressor-free extract and the presence of a small quantity of vasodilatin in a secretagogue preparation enhances its action on the intestine. 2) Secretagogues stimulate gastric secretion on application to the intestine only after a latent period of from one to three hours. If removed from the intestine during the latent period stimulation does not result. This strongly indicates that secretagogues in the intestine act primarily by being absorbed and in an accumulative manner.
京都府立医科大学の論文

胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第2編腸位相ニヨル影響

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胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第2編 腸位相ニヨル影響

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胃液分泌ニ及ボス分泌亢進物質(Secretagogues)ノ影響 : 第2編腸位相ニヨル影響