Serial Examinations of Anti-GFAP Autoantibodies in Cerebrospinal Fluids in Canine Necrotizing Meningoencephalitis(Clinical Pathology)
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概要
- 論文の詳細を見る
Canine necrotizing meningoencephalitis (NME) is characterized by autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids (CSFs). To clarify the time-course changes in autoantibodies, serial examinations were conducted in three dogs with NME (two Pugs and a Pomeranian) that were treated by immunosuppressive therapy. The Pugs retained high autoantibody titers throughout the observation periods (146 and 813 days) and died with neurological signs. On the other hand, the Pomeranian switched from being positive for autoantibody to negative after day 580, and its NME seemed to be in clinical remission until death on day 1238. Therefore, the anti-GFAP autoantibodies can be detected over time in canine NME even during immunosuppressive therapies. However, the autoantibodies can also disappear within a certain period after onset.
- 社団法人日本獣医学会の論文
- 2009-01-25
著者
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TAMAHARA Satoshi
Laboratory of Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, University o
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology Department Of Veterinary Medical Sciences Graduate Sc
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Matsuki Naoaki
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Matsuki Naoaki
Department Of Veterinary Clinical Pathobiology Graduate School Of Agriculture And Life Sciences The
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TAKAHASHI Masashi
Animal Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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YAEGASHI Masaya
Laboratory of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, T
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Tamahara Satoshi
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Ono Kenichiro
Dep. Of Veterinary Clinical Pathobiology Graduate School Of Agriculture And Life Sciences The Univ.
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology
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Yaegashi Masaya
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Takahashi Masashi
Animal Medical Center Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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