Impaired Expression of Excitatory Amino Acid Transporter 2 (EAAT2) and Glutamate Homeostasis in Canine Necrotizing Meningoencephalitis(Clinical Pathology)
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概要
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To clarify the involvement of excitatory and inhibitory amino acids in canine necrotizing meningoencephalitis (NME), glutamate, aspartate, taurine and gamma-aminobutylic acid (GABA) were determined in the cerebrospinal fluids (CSF) from eight NME cases and ten healthy controls. NME dogs exhibited significantly higher concentrations of glutamate and aspartate than those in controls (p<0.001 and p<0.001, respectively), while there was no difference in taurine or GABA between the two groups. When fetal canine astrocytes were cultured for 24hr in the presence of NME-CSF, supernatant concentrations of glutamate, aspartate and taurine were significantly elevated. Simultaneously, expression of excitatory amino acid transporter 2 (EAAT2) mRNA was significantly reduced in the astrocytes without change in EAAT1 mRNA. Hence, reduced expression of EAAT2 and impaired glutamate homeostasis may contribute to the pathogenesis of NME.
- 社団法人日本獣医学会の論文
- 2008-10-25
著者
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Pham Ngoc-thi
Laboratory Of Veterinary Clinical Pathobiology Department Of Veterinary Medical Sciences Graduate Sc
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TAMAHARA Satoshi
Laboratory of Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, University o
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology Department Of Veterinary Medical Sciences Graduate Sc
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Matsuki Naoaki
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Matsuki Naoaki
Department Of Veterinary Clinical Pathobiology Graduate School Of Agriculture And Life Sciences The
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SHIBUYA Masahiro
Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate
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Tamahara Satoshi
Laboratory Of Veterinary Clinical Pathobiology Graduate School Of Agricultural And Life Sciences The
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Ono Kenichiro
Dep. Of Veterinary Clinical Pathobiology Graduate School Of Agriculture And Life Sciences The Univ.
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Ono Kenichiro
Laboratory Of Veterinary Clinical Pathobiology
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Shibuya Masahiro
Laboratory Of Veterinary Clinical Pathobiology Department Of Veterinary Medical Sciences Graduate Sc
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