FOLFOX療法施行に伴うアレルギー反応に関する多施設共同研究

概要

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We investigated Oxaliplatin (L-OHP)-related hypersensitivity reactions in 20 Japanese patients with advanced colorectal adenocarcinomas treated with the FOLFOX 4 or mFOLFOX 6 regimen, after separating patients into a non-severe group with reactions of grade 1-2 and a severe group with reactions of grade 3-4. The total number of patients was 90, and the proportion with hypersensitivity reactions was 22.2%, rated as non-severe in 13.3% and severe in 8.9%. We observed the following: 1) hypersensitivity reactions occurred only after the 6th course in the severe group, but this was not true for the non-severe group, and 2) hypersensitivity reactions appeared within 30min of the start of L-OHP infusion in the severe group, whereas it took more than 30min for them to be manifested in the non-severe group, with the difference in time being statistically significant (p=0.001; Mann-Whitney's U test). These results strongly suggest that the severe hypersensitivity reactions were of type I and thus could be predicted from various skin tests.
2008-10-10