コアシェル型多分岐性高分子の分子放出挙動

概要

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Polyglycerol-polyethylene imine (PGL-PEI) was synthesized from glycidol and polyethylene imine (PEI) as a core-shell type hyperbranched polymer. PGL-PEI was characterized by 1H, 13C nuclear magnetic resonance (1H, 13C-NMR) spectroscopy, gel permeation chromatography (GPC). Using benzylcinamate (BC) as a guest molecule, release behavior of PGL-PEI was investigated by ultraviolet visible (UV-vis) spectroscopy. The 13C-NMR spectrum is complicated and suggests a highly branched structure for the PGL-PEI. And GPC profile of PGL-PEI gave a unimodal profile. These results suggest that the PGL-PEI was successfully prepared by the monomer slow addition method. To confirm the PGL-PEI release behavior by UV-vis measurement, the PGL-PEI after loading BC was dissolved in water at the pH 10.01. For UV-vis spectra of B-band of BC decreased with pH decreasing. We demonstrated the PGL-PEI successfully shows release behavior.