Potential Inhibitory Effects of D-Allose, a Rare Sugar, on Liver Preneoplastic Lesion Development in F344 Rat Medium-Term Bioassay(MEDICAL BIOTECHNOLOGY)
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概要
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D-Allose, the C-3 epimer of D-glucose, is a monosaccharide present in minute quantities in nature and a rare sugar. The effects of D-allose on diethyl nitrosamine(DEN)-induced hepatocarcinogenesis were examined in male F344 rats by a rat medium-term bioassay based on the two-step model of hepatocarcinogenesis(experiment 1). In addition, a DNA microarray analysis was employed to clarify possible mechanisms of action of D-allose(experiment 2). The antioxidation potential of D-allose solution itself or of serum in rats treated with D-allose was also examined directly by measuring Cu^+-reducing antioxidation power(experiment 3). Furthermore, to investigate the effects of D-allose in vivo under conditions of oxidative stress, it was administered with a choline-deficient, L-amino acid-defined diet(CDAA) in the medium-term liver carcinogenesis bioassay(experiment 4). Experiment 1 demonstrated no effects of D-allose on the development of glutathione S-transferase placental form(GST-P) positive foci in the liver. From DNA microarray analysis, several mRNA markers were found to be altered with functions related to apoptosis and cell proliferation(experiment 2), although D-allose itself and serum in vivo exhibited no antioxidation power directly(experiment 3). When D-allose was administered with the CDAA diet, decreases in the area and number of GST-P positive foci were noted with P values of 0.158 for area(%) and 0.061 for number(/cm^2)(experiment 4). These results suggest the potential inhibitory effect of D-allose on liver carcinogenesis, particularly under oxidative stress conditions.
- 社団法人日本生物工学会の論文
- 2008-05-25
著者
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IMAIDA Katsumi
Onco-Pathology, Faculty of Medicine, Department of Pathology and Host-Defense, Kagawa University
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Imaida Katsumi
Department Of Pathology And Host-defense Kagawa University
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Yokohira Masanao
Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
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Kuno Toshiya
Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
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Yamakawa Keiko
Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
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Saoo Kousuke
Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
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Hosokawa Kyoko
Onco-Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University
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Matsuda Yoko
Onco-Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University
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Zeng Yu
Onco-Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University
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Zeng Yu
Onco-pathology Department Of Pathology And Host-defence Faculty Of Medicine Kagawa University
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Saoo Kousuke
Department Of Pathology And Host-defense Kagawa University
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Hosokawa Kyoko
Onco-pathology Department Of Pathology And Host-defence Faculty Of Medicine Kagawa University
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Imaida Katsumi
Onco-pathology Faculty Of Medicine Department Of Pathology And Host-defense Kagawa University
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Yokohira Masanao
Faculty Of Medicine Kagawa University
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Kuno Toshiya
Onco-pathology Department Of Pathology And Host-defense Faculty Of Medicine Kagawa University
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Saoo Kousuke
Onco-pathology Department Of Pathology And Host-defense Faculty Of Medicine Kagawa University
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