Evaluation of Coronary Calcium Score by Multidetector Computed Tomography in Relation to Endothelial Function and Inflammatory Markers in Asymptomatic Individuals

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• Background Coronary calcification has been correlated with the presence and extent of coronary artery disease (CAD), so in the present study the associations between coronary artery calcification score (CACS) and endothelial dysfunction, as well as the important inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and oxidized low-density lipoprotein (OxLDL), were studied in asymptomatic individuals at intermediate risk for CAD. Methods and Results The study group comprised 177 subjects (103 males) aged 50.6±5.9 years. CACS was measured by multidetector computed tomography using the Agatston method. Endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent nitroglycerin-mediated dilatation (NMD) were measured by high-resolution external brachial ultrasound. Coronary artery calcification (CAC) was detected in 82 subjects (52 males), and the median CACS was 143 [31-311.25] units. After adjusting for gender and body mass index, log(CACS+1) correlated positively with age (r=0.401, p<0.001) and IL-6 levels (r=0.442, p<0.001), and negatively with FMD (r=-0.511, p<0.001). The correlations of log(CACS+1) with CRP and OxLDL levels, and with NMD, were non-significant. In a multivariate-adjusted logistic regression model, age (odds ratio (OR)=1.083 [1.014-1.156]), serum IL-6 level (OR=3.837 [2.166-6.798]) and FMD (OR=0.851 [0.793-0.913]) were significantly and independently associated with CAC. Conclusions Peripheral endothelial function inversely correlated with CACS, whereas IL-6 level was associated with CACS. Testing for endothelial function and IL-6 level may improve cardiovascular risk assessment and help target the therapeutic strategies in asymptomatic patients at intermediate CAD risk.

• 社団法人日本循環器学会の論文
• 2008-04-20

著者

• AIZAWA Yoshifusa

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• KODAMA Makoto

  Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences

• Ramadan Mahmoud

  Division Of Cardiology First Department Of Internal Medicine

• Ramadan Mahmoud

  新潟大学 医歯学総合研究科循環器学分野

• Aizawa Y

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Kodama Makoto

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• Kodama Makoto

  新潟大学 医歯学総合研究科循環器学

• Limin Ding

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Hirono Satoru

  First Department Of Medicine Niigata University School Of Medicine

• Kodama Makoto

  Division Of Cardiology Department Of Cardiovascular And Vital Control Niigata University Graduate Sc

• 相澤 好治

  北里大学・医・衛生公衛

• Mahfouz Essam

  Department of Cardiology, Mansoura Faculty of Medicine Mansoura University

• Gomaa Gamal

  Department of Cardiology, Mansoura Faculty of Medicine Mansoura University

• El-Diasty Tarek

  Department of Radiology, Mansoura Urology and Nephrology Center, Mansoura University

• Alldawi Louie

  Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of

• Ikrar Taruna

  Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of

• Aizawa Yoshifusa

  Cardiovascular Medicine Niigata University Graduate School Of Medicine

• Gomaa Gamal

  Department Of Cardiology Mansoura Faculty Of Medicine Mansoura University

• Ikrar Taruna

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Mahfouz Essam

  Department Of Cardiology Mansoura Faculty Of Medicine Mansoura University

• Alldawi Louie

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Sato Hironori

  1st. Dept. Of Intern. Med Niigata Univ. School Of Med

• Aizawa Yoshifusa

  Division Of Cardiology Niigata University Graduate School Of Medicine And Dental Sciences

• Ramadan Mahmoud

  Division Of Cardiology Department Of Internal Medicine Mansoura Faculty Of Medicine Mansoura Univers

• Hirono Satoru

  Division Of Cardiology Niigata University School Of Medical And Dental Sciences

• Mohammed Ramadan

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Aizawa Yoshifusa

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• El-diasty Tarek

  Department Of Radiology Mansoura Urology And Nephrology Center Mansoura University

• Aizawa Yoshifusa

  Division Of Endocrinology And Metabolism Department Of Homeostatic Regulation And Developments Niiga

• Ramadan Mahmoud

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

• Kodama Makoto

  First Dep. Of Medicine Graduate School Of Medical And Dental Sciences Niigata Univ.

• Aizawa Yoshifusa

  Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical An

• Ramadan Mahmoud

  Division Of Cardiology First Department Of Internal Medicine Niigata University Graduate School Of M

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