8 菌糸の異常形態を誘導する菌類代謝産物(ポスター発表の部)

概要

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Fungal metabolites inducing abnormal hyphal morphology of a phytopathogenic fungus, ex. Cochliobolus lunatus, were surveyed. From this screening, the following metabolites were identified as the active inducer of the hyphal morphology, i.e., lunatoic acid A (1), (-)-mitorubrinic acid (3), dehydroaltenusin (4), sydonol (5), terreic acid (6), mycorrhizin A (9), chloromycorrhizin A (10), pyrenolide A (11). One of the common molecular characteristics of these metabolites is high reactivities to nucleophiles such as SH-compounds. Since the adducts lost the activities, this high reactivity of molecules could relate the activities inducing abnormal hyphal morphology. From this studies a new metabolite, pyrenolide I (12), was isolated from the fungus, Pyrenophora teres, which produces pyrenolide A. The plain structure of pyrenolide I was established by spectroscopic method. Pyrenolide I showed inhibition of the cell (HL-60) (IC_<50> 4ug/ml). Another new metabolites having the activity of inducing abnormal hyphal morphology were isolated from an unidentified fungus. The structure of the one was established as 13 by spectroscopic and chemical methods.
天然有機化合物討論会の論文
1988-09-26