84 ヤエヤマシキミ葉の成分研究 : 新しいphytoquinoidの構造と生理活性について

概要

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Phytoquinoids are known only few examples occurring in higher plants, and are of interest in exhibiting both antitumor and cytotoxic activities. We here report the isolation and structure elucidations of novel phytoquinoids and their analogues from leaves of Illicium tashiroi Maxim. (Japanese name, Yaeyama-shikimi, Illieiaceae) collected on Iriomote island. The structure of illicinone-A (13) have been determined on the basis of the results of spectral and chemical analyses. And the structures of illicinone-B, -C, and -D were assigned with formulae 14, 15, and 16, respectively, by the comparisons of PMR and CMR spectra with those of illicinone-A (13) and by the chemical correlations with illicinone-A. The absolute configurations of illicinones were elucidated by CD spectra of 20 and 21 derived from illicinone-A (13) by the treatments of NaBH_4, H^+, and Pd-C/H_2, successively. The structures of illifunone-A (22), -B (23), -C (24), and -D (25) were also proposed by spectral evidences. Furthermore, some biological activities of illicinones were discussed.
天然有機化合物討論会の論文
1980-09-10