Furo[2,3-c]isoquinoline誘導体の合成
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概要
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Reaction of 1-phenylfuro [2,3-c] isoquinolin-5 (4H)-one (IIIa) with acetyl nitrate and bromine in the presence of ethanol or water gave 1,2,3,4-tetrahydroisoquinolines (IV and VI). 5-Chloro-1-phenylfuro [2,3-c] isoquinoline-2-carbaldehyde (VII) was obtained from the Vilsmeir formylation of IIIa and 5-chloro-1-phenylfuro [2,3-c] isoquinoline (VIII). Nitration of VIII with acetyl nitrate gave 5-chloro-2-nitro-1-phenylfuro [2,3-c] isoquinoline (IX) and 2,5-dichloro-1-phenylfuro [2,3-c] isoquinoline (X). 3-Alkyl-7-phenylfuro [2,3-c]-sym-triazolo [3,4-a] isoquinolines (XIIIa-c) and Shiff's bases (XIVa-c) were prepared from the condensation of 5-hydrazino-1-phenylfuro [2,3-c] isoquinoline (XII) with aliphatic acids and aromatic aldehydes.
- 公益社団法人日本薬学会の論文
- 1980-03-25
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関連論文
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- Furo[2,3-c]isoquinoline誘導体の合成