Mitogen-activated Protein Kinase Inhibitors Induce Apoptosis and Enhance the Diallyl Disulfide-induced Apoptotic Effect in Human CNE2 Cells
スポンサーリンク
概要
- 論文の詳細を見る
In this study, we investigated whether the inhibition of endogenous phosphorylation of mitogen-activated protein kinase (MAPK) and diallyl disulfide (DADS)-induced phosphorylation of MAPKs with MAPK specific inhibitors, SB203580 and U0126 (for phospho-p38 and phospho-p42/p44, respectively), can induce or enhance apoptosis in human CNE2 nasopharyngeal carcinoma cells. Our data demonstrate that MAPK inhibitors decrease the viability of CNE2 cells, stimulate typical apoptotic morphologic changes, and enhance DADS-induced apoptosis. The present findings indicate that phosphorylation of MAPKs plays an important cytoprotective role in CNE2 cell apoptosis and the DADS-induced apoptotic process.
- 社団法人日本薬学会の論文
- 2008-04-01
著者
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Wang Xiao
Department of Medical Microbiology, Shandong University School of Medicine
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Xiao Jian
Research Institute For Molecular Pharmacology And Therapeutics Central South University
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Xu Ming
Research Institute For Molecular Pharmacology And Therapeutics Central South University:department O
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Wen Jun
Research Institute for Molecular Pharmacology and Therapeutics, Central South University
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Zhang Yi
Research Institute for Molecular Pharmacology and Therapeutics, Central South University
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Nie Ya
Research Institute for Molecular Pharmacology and Therapeutics, Central South University
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Talbot Simon
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center
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Li Gloria
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center
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Talbot Simon
Department Of Radiation Oncology Memorial Sloan-kettering Cancer Center
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Li Gloria
Department Of Radiation Oncology Memorial Sloan-kettering Cancer Center
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Li Gloria
Department Of Medicine The University Of Hong Kong
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Wang Xiao
Department Of Medical Laboratories Xiangya Medical College Of Central-south University
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Nie Ya
Research Institute For Molecular Pharmacology And Therapeutics Central South University
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Zhang Yi
Research And Development Division Biomira Inc.
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Wang Xiao
Department Of Electrical Engineering Faculty Of Engineering Osaka University
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Wang Xiao
Department Of Applied Physics And Materials Research Center The Hong Kong Polytechnic University
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Zhang Yi
Research Institute For Molecular Pharmacology And Therapeutics Central South University
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Wen Jun
Research Institute For Molecular Pharmacology And Therapeutics Central South University
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Wang Xiao
Department Of Aeronautical Engineering Nagoya University
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