頸髄損傷者の体水分における細胞内外液分布の特徴

概要

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People with cervical spinal cord injury (SCI) have motor and sensory dysfunction in the upper limbs as well as in the lower limbs (quadriplegia) and high risk of cardiovascular diseases. Muscle atrophy occurred with motor dysfunction induces accelerated catabolism of muscle cell protein and may alter distribution of body fluid. We examined intra-cellular water (ICW), extra-cellular water (ECW), and skeletal muscle mass of eight male with cervical-6th SCI (SCI; age, 34.1±2.4 yr, mean ± SE) and eight healthy age-, height-, waist circumference-matched male controls (CON). In results, ECW divided by weight was not different between CON (24.9±0.8%) and SCI (26.3±1.2%), although ICW was significantly lower in SCI (CON, 39.1±0.8% vs. SCI, 25.5±1.9%, p<0.001). The muscle mass was highly correlated with ICW (r=0.905, p<0.001), but not with ECW (r=0.591, p<0.05). The ratio of ICW and ECW was significantly lower in SCI than in CON (p<0.001), and significantly lower in leg than in arm in SCI (p<0.05). The results suggest that muscle atrophy induce the decrease of ICW and comparative increase of ECW in the subjects with cervical SCI. This alteration in the distribution of body fluid might be related the high risk of cardiovascular diseases in the people with cervical SCI.
日本運動生理学会の論文
2008-02-29