ラットにおける塩化アリルの神経毒性 : 長期曝露における量・影響関係

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To elucidate the dose-effect relationship of neurotoxicity of allyl chloride (AC) in Donryu rats, 5 animals each ware exposed to 10, 50 and 100ppm AC for 8 h/d and 5 d/wk for a period of 34 wk. Nerve conduction velocities of the tail nerve in rats were determined before and after 4, 8, 12, 16, 22, 28 and 34 wk of exposure, and the width of landing foot-spread after 8, 12, 16, 28 and 34wk. Animals subjected to 100ppm AC showed significant (p<0.01) reduction of motor and sensory nerve conduction velocities and nerve action potentials (NAP) after 28 wk when clinical signs of neuropathy were obeserved, i.e., weakness of hindlimbs and significantly (p<0.01) extended landing foot-spreads. Motor distal latency was retarded in rats exposed to 100ppm AC at the last period of exposure. In rats exposed to 50 and 100ppm AC, no remarkable electrophysiological findings or abnormal clinical signs were observed except for depressed amplitude of NAP in 50ppm-exposed rats when compared with those exposed to 10ppm.
社団法人日本産業衛生学会の論文
1991-03-20