トリクロロエチレンによる実験的ラット腸管嚢腫様気腫症作成の失敗

概要

論文の詳細を見る
In recent years it has been suggested in Japan that occupational trichloroethylene exposure will induce primary pneumatosis cystoides intestinalis coli. A series of two experiments were conducted to ascertain the cause-effect relationship between trichloroethylene and pneumatosis as follows: 1) In the first experiment, 12 male rats of Fischer strain were exposed to trichloroethylene at a nearly lethal concentration for 12wk. Five out of 12 rats died during the experiment, and body weight gain was extremely depressed. However, neither pneumatosis nor histological changes were observed. No changes were observed in 4 control rats as well. 2) In the second experiment, 38 male rats of Sprague-Dawley strain were exposed to 800, 200 or 50ppm trichloroethylene over a period of 12wk. Two out of 13 rats of the 800ppm group died, and body weight gain was suppressed. Mild suppression in body weight gain was also observed in the 200ppm group. However, pneumatosis was not observed in any rats of trichloroethylene groups. No pathological changes were observed in 13 rats of the control group. The foregoing results suggest that trichloroethylene cannot induce pneumatosis cystoides intestinalis in rats of these two strains. Inasmuch as rats are not prone to develop pneumatosis, the possibility for trichloroethylene to induce this disease in man cannot be denied.
社団法人日本産業衛生学会の論文
1986-07-20