閉塞性動脈硬化症に対するアフェレシス(<特集>動脈硬化とアフェレシス)

概要

論文の詳細を見る
As for the apheresis therapy for arteriosclerosis obliterans (ASO), there is a method for the removal of the etiologic agent represented by oxidation LDL and a chylomicron remnant. Degradation of blood/plasma viscosity, a change of hemorheology, vasodilator action and improvement of a vascular endothelium function are the positive effects. On the other hand, the onset of an arterial sclerosis lesion and depression of development as well as development of collateral circulation can also result from persistent effect by iteration treatment. Double filtration plasmapheresis (DFPP) is undertaken most widely. It is a method to adsorb LDL using a dextran sulfate LDL adsorber. In addition, new methods are being developed, such as warm and recirculate separated plasma, or direct LDL apheresis. Resultant improvements in peripheral blood flow shown by lowered limb pain when walking or improvement in ulcerations are found in both methods. We hope to develop a treatment to contribute to critical prevention of systemic cardiovascular disease as well as ASO in future.
日本アフェレシス学会の論文
2008-02-29