1024 QCMを利用したアンモニアガスセンサによる血液透析量測定(G02-3 バイオエンジニアリング(3),G02 バイオエンジニアリング)

概要

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Recently, expired gases are analyzed non-invasively for monitoring the substances in the blood. Breath ammonia has been shown to correlate with blood urea nitrogen (BUN) which are indicators of solute removal in hemodialysis. In this study, breath ammonia concentration was continuously measured using a crystal oscillator Quartz Crystal Microbalance (QCM) during the expiration of patients undergoing dialysis treatment. The results show that NH_3 decreased gradually as the treatment proceeded. A strong correlation was observed between changes in the frequency of the QCM gas sensor and both the pre-dialysis BUN level (r=0.71, p<0.05) and the post-dialysis BUN level (r=0.90, p<0.05). NH_3 was found to fall precipitously during dialysis. The differences were statistically significant. In addition, we found a statistically significant correlation between BUN and NH_3 in expired gas. These results suggest that continuous measurement of NH_3 is useful to assess the status of solute removal during hemodialysis.
一般社団法人日本機械学会の論文
2007-09-07