Evaluation of Genetic and Developmental Toxicity of Surfactin C from Bacillus subtilis BC1212
スポンサーリンク
概要
- 論文の詳細を見る
Surfactin C is a biosurfactant produced by Bacillus subtilis from Korean soybean paste. Surfactin C is known to have several therapeutic effects including anti-inflammatory, fibrinolytic, and thrombolytic activities. However, there is little information concerning its safety. In this study, we evaluated the genetic and developmental toxicity of surfactin C. Bacterial reverse mutation and rodent micronucleus assays were performed to determine its genotoxic potentials. Surfactin C at 0, 125, 250, and 500mg/kg of body weight/day was administered orally to pregnant ICR mice during the period of major organogenesis. There was no genetic toxicity related to surfactin C treatment in in vitro and in vivo systems. In the developmental study, surfactin C did not demonstrate maternal toxicity, fetotoxicity, and teratogenicity, and hence the no observed effect level was concluded 500mg/kg per day in ICR mice.
- 公益社団法人日本薬学会の論文
- 2008-02-01
著者
-
Lim Jong-Hwan
B&C Biopharm, Advanced Institutes of Convergence Technology
-
YUN Hyo-In
College of Veterinary Medicine, Chungnam National University
-
PARK Seung-Chun
College of Veterinary Medicine, Kyungpook National University
-
Kim Mi-hee
College Of Veterinary Medicine Kyungpook National University
-
Yun Hyo-in
Coll. Of Veterinary Medicine Chungnam National Univ.
-
Yun H‐i
Chungnam National Univ. Taejon Kor
-
Yun Hyo-in
College Of Veterinary Medicine Chungnam National University
-
Park Seung-chun
Coll. Of Veterinary Medicine Kyungpook National Univ.
-
Park S‐c
Chungnam National Univ. Taejon Kor
-
Lim Jong-hwan
Department Of Forest Environment Korea Forest Research Institute
-
Park Seung-chun
College Of Veterinary Medicine Kyungpook National University
-
Hwang Youn-Hwan
College of Veterinary Medicine, Chungnam National University
-
Kim Myoung-Seok
College of Veterinary Medicine, Chungnam National University
-
Song In-Bae
College of Veterinary Medicine, Chungnam National University
-
Park Byung-Kwon
JUNJINBIO
-
Lim Ji
Department Of Veterinary Surgery College Of Veterinary Medicine Seoul National University
-
Lim Jong‐hwan
Department Of Forest Environment Korea Forest Research Institute (kfri)
-
Hwang Youn-hwan
Inst. Of Veterinary Sci. Chungnam National Univ.
-
Song In-bae
Laboratory Of Veterinary Pharmacology And Toxicology College Of Veterinary Medicine Chungnam National University
関連論文
- Pharmacokinetics of Toltrazuril and Its Metabolites, Toltrazuril Sulfoxide and Toltrazuril Sulfone, after a Single Oral Administration to Pigs
- ブタにおけるタイロシン-フロルフェニコール併用剤の二つの異なる用量での単回筋肉内投与後のタイロシンあるいはフロルフェニコールの比較薬物動態(薬理学)
- Changes in quality of Phellinus gilvus mushroom by different drying methods
- Antibacterial Substance Produced by Streptococcus faecium under Anaerobic Culture
- 犬の実験的慢性関節炎に対する刺針療法の有効性のサーモグラフィーによる評価(外科学)
- Subacute (28 day) Toxicity of Surfactin C, a Lipopeptide Produced by Bacillus subtilis, in Rats
- Evaluation of Genetic and Developmental Toxicity of Surfactin C from Bacillus subtilis BC1212
- HydroKorea and CarboKorea : cross-scale studies of ecohydrology and biogeochemistry in a heterogeneous and complex forest catchment of Korea
- Evaluation of developmental toxicity and placental transfer of the new fluoroquinolone DW-116 in rats (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Meth A腫瘍の腹腔内増殖過程におけるサイトカイン誘導一酸化窒素合成の抑制(免疫学)
- In Vitro Antioxidant and Anti-Inflammatory Activities of Protocatechualdehyde Isolated from Phellinus gilvus
- Antiinflammatory and Antioxidant Effects of Aqueous Extract from Phellinus gilvus in Rats
- 2種のnorfloxacin化合物をウサギに経口投与したときの体内動態の比較(短報)
- Determination of roxithromycin residues in the flounder muscle with electrospray liquid chromatography-mass spectrometry
- Phellinus gilvusより抽出した多糖体のラットにおける皮膚創傷治癒の増強効果(短報)(実験動物学)
- Inter-annual and inter-plot variations of wood biomass production as related to biotic and abiotic characteristics at a deciduous forest in complex terrain, Korea
- In Vitro Antioxidant and Anti-Inflammatory Activities of Protocatechualdehyde Isolated from Phellinus gilvus
- General Feature Extraction for Mapping and Localization of a Mobile Robot Using Sparsely Sampled Sonar Data
- Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats
- Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats
- Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Protective Effects of Platycodon grandiflorum AqueousExtract on Thioacetamide-induced Fulminant HepaticFailure in Mice
- Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice
- The In Vitro Activity of 15 Antimicrobial Agents against Bacterial Isolates from Dogs
- Pharmacokinetics and Metabolism of Toltrazuil and Its Major Metabolites after Oral Administration in Broilers