Protective Effects of Platycodon grandiflorum AqueousExtract on Thioacetamide-induced Fulminant HepaticFailure in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. The group treated with BC703 at doses of 1, 5, and 10 mg/kg produced significant hepatoprotective effects against TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation in dose-dependent manners. Histopathological studies further substantiated the protective effect of BC703. These results show the hepatoprotective activity of aqueous extract from Platycodon grandiflorum on thioacetamide-induced fulminant hepatic failure.
著者
-
Yun Hyo-in
College Of Veterinary Medicine Chungnam National University
-
Park S‐c
Chungnam National Univ. Taejon Kor
-
Song In-Bae
College of Veterinary Medicine, Chungnam National University
-
Lim Ji
Department Of Veterinary Surgery College Of Veterinary Medicine Seoul National University
-
Suh Joo-won
Division Of Bioscience And Bioinformatics College Of Natural Science Myongji University
-
KIM Myoung-Seok
Jeollanamdo Development Institute for Traditional Korean Medicine
-
Lim Jong-Hwan
B Biopharm, Advanced Institutes of Convergence Technology, Gyeonggi-Do 443-270, South Korea
-
Kim Tae-Won
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
-
Park Sang-Jin
B Biopharm, Advanced Institutes of Convergence Technology, Gyeonggi-Do 443-270, South Korea
-
Kwon Hyo-Jung
Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
-
Cho Eun-Sang
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
-
Son Hwa-Young
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
-
Lee Sang-Wook
B Biopharm, Advanced Institutes of Convergence Technology, Gyeonggi-Do 443-270, South Korea
-
Kim Jong-Woo
B Biopharm, Advanced Institutes of Convergence Technology, Gyeonggi-Do 443-270, South Korea
-
Son Hwa-young
College Of Veterinary Medicine Chungnam National University
-
Kwon Hyo-jung
Laboratory Of Liver Diseases National Institute On Alcohol Abuse And Alcoholism National Institutes Of Health
-
Cho Eun-sang
College Of Veterinary Medicine Chungnam National University
-
Song In-Bae
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
-
Kim Myoung-Seok
Jeollanamdo Development Institute for Traditional Korean Medicine, Jeollanam-Do 529-851, South Korea
-
KIM Tae-Won
College of Veterinary Medicine, Chungnam National University
-
Yun Hyo-In
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
関連論文
- Pharmacokinetics of Toltrazuril and Its Metabolites, Toltrazuril Sulfoxide and Toltrazuril Sulfone, after a Single Oral Administration to Pigs
- ブタにおけるタイロシン-フロルフェニコール併用剤の二つの異なる用量での単回筋肉内投与後のタイロシンあるいはフロルフェニコールの比較薬物動態(薬理学)
- Antibacterial Substance Produced by Streptococcus faecium under Anaerobic Culture
- 犬の実験的慢性関節炎に対する刺針療法の有効性のサーモグラフィーによる評価(外科学)
- Subacute (28 day) Toxicity of Surfactin C, a Lipopeptide Produced by Bacillus subtilis, in Rats
- Evaluation of Genetic and Developmental Toxicity of Surfactin C from Bacillus subtilis BC1212
- Evaluation of developmental toxicity and placental transfer of the new fluoroquinolone DW-116 in rats (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 2種のnorfloxacin化合物をウサギに経口投与したときの体内動態の比較(短報)
- Determination of roxithromycin residues in the flounder muscle with electrospray liquid chromatography-mass spectrometry
- In Vitro Antioxidant and Anti-Inflammatory Activities of Protocatechualdehyde Isolated from Phellinus gilvus
- Hypertonic Stress Increased Extracellular ATP Levels and the Expression of Stress-Responsive Genes in Arabidopsis thaliana Seedlings
- Intracellular ATP Levels Affect Secondary Metabolite Production in Streptomyces spp.
- S-Adenosyl-L-methionine Activates Actinorhodin Biosynthesis by Increasing Autophosphorylation of the Ser/Thr Protein Kinase AfsK in Streptomyces coelicolor A3(2)
- Intracellular ATP Levels Affect Secondary Metabolite Production in Streptomyces spp.
- Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats
- Phosphoprotein affinity purification identifies proteins involved in S-adenosyl-L-methionine-induced enhancement of antibiotic production in Streptomyces coelicolor
- Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Protective Effects of Platycodon grandiflorum AqueousExtract on Thioacetamide-induced Fulminant HepaticFailure in Mice
- Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice
- Histological and Genetic Characterization of True Hermaphroditism in Korean Pigs
- Pharmacokinetics and Metabolism of Toltrazuil and Its Major Metabolites after Oral Administration in Broilers