Intracellular ATP Levels Affect Secondary Metabolite Production in Streptomyces spp.
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概要
- 論文の詳細を見る
The addition of extracellular ATP (exATP) to four Streptomyces strains had similar effects: low exATP levels stimulated antibiotic production and high levels reduced it. Compared with antibiotic production, the concentrations of intracellular ATP (inATP) in the tested strains were opposite, which suggests a role of inATP in regulating secondary metabolite production. Under inactivation of the polyphosphate kinase gene (ppk) in Streptomyces lividans, we observed the same results: when the inATP level in the mutant strain was lower than in the parent strain, more antibiotic was produced. Combining all the results, a strong inverse relationship between [inATP] and the secondary metabolite production is suggested by this study.
- 社団法人 日本農芸化学会の論文
著者
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LI Ming
Center for Optoelectronics, Department of Electrical Engineering, National University of Singapore
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MENG Lingzhu
Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University
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Yang Seung
Division Of Bioscience And Bioinformatics College Of Natural Science Myongji University
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Suh Joo-won
Division Of Bioscience And Bioinformatics College Of Natural Science Myongji University
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Kim Tae-jong
Department Of Infectious Diseases College Of Veterinary Medicine Konkuk University
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Meng Lingzhu
Div. Of Bioscience And Bioinformatics Coll. Of Natural Sci. Myongji Univ.
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Meng Lingzhu
Division Of Bioscience And Bioinformatics College Of Natural Science Myongji University
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