Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae)
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概要
- 論文の詳細を見る
Three new minor labdane diterpene glycosides, forskoditerpenoside C, D, and E (1-3), and a novel labdane diterpene forskoditerpene A (4) were isolated from the ethanol extract of the whole plant of Coleus forskohlii. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analyses including 1D-, 2D-NMR, and HR-ESI-MS experiments. Compounds 1-3 showed an unusual 8,13-epoxy-labd-14-en-11-one glycoside pattern. They showed relaxative effects on isolated guinea pig tracheal spirals in vitro. Compound 4 with a cyclopropyl, confirmed by a single-crystal X-ray diffraction determination, is the first known labdane derivative with a spiro element.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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LU Yang
Institute of Materia Medica, The Chinese Academy of Medical Sciences
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NIWA Masatake
Faculty of Pharmacy, Meijo University
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Lu Yang
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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Niwa Masatake
Faculty Of Pharmacy Meijo University
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Niwa M
Faculty Of Pharmacy Meijo University
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Niwa Masatake
Fac. Of Pharmacy Meijo Univ.
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Xu Lingling
Department of Nephrology, 2nd Affiliated Hospital of Nanjing Medical University
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SHAN Yupei
Department of Natural Medicinal Chemistry, China Pharmaceutical University
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WANG Xiaobing
Department of Natural Medicinal Chemistry, China Pharmaceutical University
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ZHENG Qitai
Institute of Materia Medica, Chinese Academy of Medical Sciences
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KONG Lingyi
Department of Natural Medicinal Chemistry, China Pharmaceutical University
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Shan Yupei
Department Of Natural Medicinal Chemistry China Pharmaceutical University
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Zheng Qitai
Institute Of Materia Medica Chinese Academy Of Medical Sciences
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Kong Lingyi
Department Of Natural Medicinal Chemistry China Pharmaceutical University
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Wang Xiaobing
Department Of Natural Medicinal Chemistry China Pharmaceutical University
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Xu Lingling
Department Of Natural Medicinal Chemistry China Pharmaceutical University
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