Inhibition of Human Gastric Carcinoma Cell Growth in Vitro and in Vivo by Cladosporol Isolated from the Paclitaxel-Producing Strain Alternaria alternata var. monosporus

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概要

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• Cladosporol was isolated from the fermentation broth of Alternaria alternata var. monosporus obtained from the inner bark of the yew tree and mutated for many generations. We investigated the antitumor effects of cladosporol in vitro and in vivo. The growth-inhibitory effects of cladosporol in vitro against six human cancer cell lines were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The results showed that cladosporol selectively killed cancer cells and had a significant inhibitory effect on the human gastric carcinoma cell line MGC-803 in a concentration- and time-dependent manner. In vivo, cladosporol also showed antitumor activity in nude mice bearing MGC-803 gastric cancer xenografts. These findings suggest that cladosporol has potentially useful growth inhibitory effects on human gastric carcinoma cell lines.

• 公益社団法人　日本薬学会の論文

著者

• KONG Lingyi

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• Kong Lingyi

  Department Of Natural Medicinal Chemistry China Pharmaceutical University

• Luo Jianguang

  Department Of Computer Science And Technology Tsinghua University

• Chen Jiepeng

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• Qiu Xuelian

  Strand Biotechnology Institute of Research

• Wang Ronghua

  Strand Biotechnology Institute of Research

• Duan Lili

  Strand Biotechnology Institute of Research

• Chen Shouxian

  Strand Biotechnology Institute of Research

• Luo Jianguang

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

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