Edaravone, a Potent Free Radical Scavenger, Prevents Anthracycline-Induced Myocardial Cell Death
スポンサーリンク
概要
- 論文の詳細を見る
Background It was investigated whether edaravone, a potent free radical scavenger, would protect against anthracycline-induced cardiotoxicity and prevent cardiac function deterioration. Methods and Results Cultured neonatal rat cardiomyocytes were stimulated by daunorubicin 1μmol/L either with or without edaravone or superoxide dismutase mimetic Mn (III) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP). Cell viability was estimated by measuring the amount of lactate dehydrogenase (LDH) released into the culture medium. Apoptosis was determined by a caspase-3 activity assay and a histone-DNA complex fragment assay. To investigate whether edaravone interfered with daunorubicin's antitumor effect, daunorubicin and edaravone were added to human leukemia K562 cells, and the surviving cells were counted. In addition, edaravone's in vivo effect was evaluated using Sprague-Dawley rats. A total of 15mg/kg doxorubicin was injected intraperitoneally either with or without simultaneous edaravone injection. Two and 6 weeks after the final injection, left ventricular diastolic diameter and left ventricular fraction shortening were assessed echocardiographically. The LDH assay showed that edaravone significantly inhibited LDH release from cardiac myocytes (p=0.0428). The caspase-3 activity and histone-DNA complex fragment assays demonstrated that edaravone's apoptosis suppression effect was much weaker than that of MnTMPyP. The in vivo study showed that edaravone prevented doxorubicin-induced cardiac deterioration. Finally, edaravone was found to not affect daunorubicin's anticancer effect on K562 cells. Conclusions Edaravone protects cardiomyocytes from anthracycline-induced cardiotoxicity via an anti-necrotic rather than an anti-apoptotic effect. (Circ J 2007; 71: 1815-1820)
- 社団法人日本循環器学会の論文
- 2007-10-20
著者
-
FUKAZAWA RYUJI
Department of Pediatrics, Nippon Medical School
-
OGAWA SHUNICHI
Department of Pediatrics, Nippon Medical School
-
WATANABE Makoto
Department of Preventive Cardiology, National Cardiovascular Center
-
Ikegami Ei
Department of Pediatrics, Nippon Medical School
-
Katsube Yasuhiro
Department ot Pediatrics, Nippon Medical School
-
Kamisago Mitsuhiro
Department ot Pediatrics, Nippon Mediccl School
-
ABE Masanori
Department of Community Medicine, Ehime University Graduate School of Medicine
-
Ogawa Shunichi
Department Of Pediatrics Nippon Medical School
-
WATANABE MIKI
Department of Rheumatology and Hematology, Tohoku University School of Medicine
-
Hajikano Miharu
Department of Pediatrics, Nippon Medical School
-
Ikegami Ei
Department Of Pediatrics Nippon Medical School Hospital
-
Ikegami Ei
Department Of Pediatrics Nippon Medical School
-
Fukazawa Ryuji
Department Of Pediatrics Nippon Medical School
-
Katsube Yasuhiro
Department Of Pediatrics Nippon Medical School
-
Kanbe Masaru
Department of Surgery, Cardiovascular Surgery, Nippon Medical School
-
Kamisago Mitsuhiro
Department Of Pediatrics Nippon Medical School
-
Abe Masanori
Department Of Pediatrics Nippon Medical School
-
Watanabe Miki
Department Of Pediatrics Cardiovascular Surgery Nippon Medical School
-
Watanabe Makoto
Department Of Cardiology Hirai Hospital
-
Hajikano Miharu
Department Of Pediatrics Nippon Medical School
-
Katsube Yasuhiro
Department Ot Pediatrics Nippon Medical School
-
Kanbe Masaru
Department Of Surgery Cardiovascular Surgery Nippon Medical School
-
Abe Masanori
Department Of Anesthesiology Faculty Of Medicine University Of The Ryukyus
-
Watanabe Makoto
Department Of Cardiology Anjo Kosei Hospital
-
Watanabe Makoto
Department Of Analytical Chemistry Of Medicines. Showa Pharmaceutical University
-
Watanabe Makoto
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
関連論文
- Stromal cell-derived factor-1αは血管新生を通じて心筋梗塞後の心機能を改善する
- Risk of Smoking and Metabolic Syndrome for Incidence of Cardiovascular Disease : Comparison of Relative Contribution in Urban Japanese Population : The Suita Study
- Effect of chronic kidney disease on individual and population medical expenditures in the Japanese population
- Bone marrow stromal cell-mediated gene delivery into infarcted heart
- Circulating bone marrow-derived cells differentiate into cardiomyocytes in infarcted heart
- The role of Mac-1 and myeloid-related protein (MRP) for causing vasculitis in Kawasaki disease, and the effects of gamma globulin
- 加算平均心電図による川崎病既往児心筋病変の評価
- PJ-351 Cardiac Diffusion-weighted MRI Compensates for T2-weighted Imaging in the Detection of Infarct-related Myocardial Edema(MRI/MRA(03)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-377 Papillary Muscle Gadolinium Late Enhancement : Frequency and Relationship with Mitral Regurgitation(MRI/MRA(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Alcohol Consumption Is Associated with Decreased Insulin Resistance Independent of Body Mass Index in Japanese Community-Dwelling Men
- Colorectal Cancer and Serum C-reactive Protein Levels : a Case-control Study Nested in the JACC Study
- Prognostic Value of Q Wave for Cardiovascular Death in a 19-Year Prospective Study of the Japanese General Population
- Relationships between Protein Intake and Renal Function in a Japanese General Population : NIPPON DATA90
- Protein Intakes and Serum Albumin Levels in a Japanese General Population : NIPPON DATA90
- Delayed response of transcranial myogenic motor-evoked potential monitoring to spinal cord ischemia during repair surgery for descending thoracic aortic aneurysm
- Long-term outcome of catheter intervention in Kawasaki Disease : Multi-institutional study
- Guidelines for catheter intervention in coronary artery lesion in Kawasaki disease
- OE-318 Inositol 1,4,5-Trisphosphate 3-Kinase C Polymorphism Associated with Disease Severity and Coronary Artery Lesions in Kawasaki Disease(OE54,Congenital Heart Disease/Kawasaki's Disease (M),Oral Presentation (English),The 73rd Annual Scientific Meetin
- OE-414 How TNFα Receptor Polyorphism Affect the State of Kawasaki Disease?(Congenital heart disease/Kawasaki's disease(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-157 How MCP-1 and CCR2 Gene Polymorphism Affect Clinical Course of Kawasaki Disease?(Congenital heart disease/Kawasaki's disease-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Fc Gamma IIIa Receptor 158V/F Polymorphism and Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Search for Outer Massive Bodies around Transiting Planetary Systems : Candidates of Faint Stellar Companions around HAT-P-7
- Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease
- ズリ応力の低下、乱流は冠動脈瘤および血栓形成を惹起する
- AT1 Blocker Protects Excessive Remodeling of Coronary Artery in Patients with Kawasaki Disease
- The Effect of Immunoglobulin Therapy on Human Endothelial Cell in Kawasaki Disease
- Hemodynamic factors of thrombus formation in coronary aneurysms associated with Kawasaki disease
- Changes in Endothelium-Derived Vascular Regulatory Factors During Dobutamine-Stress-Induced Silent Myocardial Ischemia in Patients With Kawasaki Disease
- Birth Cohort Effect of the Mortality Rate from Congenital Heart Disease in Japan
- An 8-year-old boy with vertebral artery dissection with cerebellar ataxia featuring suspected vertebral artery hypoplasia
- Interventional treatment for fetus and newborn infant with congenital heart disease
- One and a Half Ventricle Repair for Ebstein's Anomaly
- Seroepidemiology of hepatitis B virus infection among children in Mongolia : Results of a nationwide survey
- Impact of the Universal Hepatitis B Immunization Program in Mongolia : Achievements and Challenges
- Associations between dietary intake and breast milk dioxin levels in Tokyo, Japan
- 川崎病巨大冠動脈瘤の危険因子としての検査データ
- Case-control study of giant coronary aneurysms due to Kawasaki disease
- Respiratory Symptoms Correlating to Smoking Prevalence : The National Nutrition Survey and the National Life-style Survey in Japan
- Edaravone, a Potent Free Radical Scavenger, Prevents Anthracycline-Induced Myocardial Cell Death
- Coronary Artery Aneurysm Induced by Kawasaki Disease in Children Show Features Typical Senescence
- OE-156 The expression of Macrophage Chemoattractant Protein-1 in Remote Phase Kawasaki Disease Aneurysm(Congenital heart disease/Kawasaki's disease-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-325 Characteristic Senescence Associated Findings in Coronary Artery Aneurysm in Children with Kawasaki Disease(Atherosclerosis, Clinical 6 (IHD) : PE56)(Poster Session (English))
- IS139 Differential Signaling by Epidermal Growth Factor and Neuregulin in Rat Cardiac Myocytes and Microvascular Endothelial Cells
- Geographic Difference of Mortality of Creutzfeldt-Jakob Disease in Japan
- A Case of "Disease of the Intercalated Disc" Demonstrated in Obstructive Cardiomyopathy
- Monthly Observation of the Number of Patients with Kawasaki Disease and its Incidence Rates in Japan : Chronological and Geographical Observation from Nationwide Surveys
- Epidemiologic Features of Kawasaki Disease in Japan : Results from the Nationwide Survey in 2005-2006
- Mortality Among Persons With a History of Kawasaki Disease in Japan : Mortality Among Males With Cardiac Sequelae is Significantly Higher Than That of the General Population
- Flexible ex vivo phantoms for validation of diffusion tensor tractography on a clinical scanner
- Dual Gradient-echo In-phase and Opposed-phase Magnetic Resonance Imaging to Evaluate Lipomatous Metaplasia in Patients with Old Myocardial Infarction
- Revision of diagnostic guidelines for Kawasaki disease : the 5th revised edition
- Ferrite Plating of Fe_3O_4 Films on Expanded Polytetrafluoroethylene Modified by Xe Excimer Lamp
- Ferrite Plating of Ba-Containing Iron Oxide Films Using Chelated Highly Alkaline (pH=11-13) Aqueous Solutions
- Preparation of Co_xFe_O_4 Films in Aqueous Solution at 120-200℃ by "Hydrothermal Ferrite Plating"
- Cardiovascular function before and after iron therapy by echocardiography in patients with iron deficiency anemia
- Engineering immune therapy against hepatitis B virus
- Ultrasonic Power Doppler Imaging for Prostatic Cancer : A Preliminary Report
- Aberrant halt of syringe pump motion : an improved system to prevent false setting of the syringe
- 塩酸ドブタミン負荷体表面電位図による川崎病既往児の心筋虚血の評価
- High Sensitivity InSb Hall Effect Biosensor Platform for DNA Detection and Biomolecular Recognition Using Functionalized Magnetic Nanobeads
- High Sensitivity InSb Ultra-Thin Film Micro-Hall Sensors for Bioscreening Applications
- Criteria for Evaluating Abnormal Signal-Averaged Electrocardiogram in Children Classified by Age, Body Surface Area and Height
- Tumorous deformity of mitral valve leaflet after chordal rupture in a child
- 高用量ドブタミン負荷心エコー図法を用いたアントラサイクリン投与を受けた小児がん患者における心予備能の検討
- Longitudinal evaluation of anthracycline cardiotoxicity by signal-averaged electrocardiography in children with cancer
- S L_-Absorption Spectra of CdS and ZnS
- SYSTOLIC TIME INTERVALS IN AORTIC INSUFFICIENCY
- HEMODYNAMIC CORRELATION WITH PHONOCARDIOGRAM IN AORTIC INSUFFICIENCY
- HEMODYNAMIC AND CINERADIOGRAPHIC ANALYSIS OF CARDIODYNAMICS: MYOCARDIAL CONTRACTILE STATE IN ACUTE AND SUBACUTE PHASE OF EXPERIMENTAL MYOCARDIAL INFARCTION
- EFFICACY OF LAPAROSCOPIC RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA COMPARED TO PERCUTANEOUS RADIOFREQUENCY ABLATION WITH ARTIFICIAL ASCITES
- Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis
- LAPAROSCOPIC FEATURES AND INTEROBSERVER VARIATION OF HISTOLOGICAL DIAGNOSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
- Clinical usefulness of quantitative evaluation of visceral fat by ultrasonography
- Clinical features of symptomatic primary biliary cirrhosis initially complicated with esophageal varices
- Clinical characteristics of autoimmune hepatitis in older aged patients
- 低出生体重児に対する喫煙の日本における人口寄与割合
- Diastereoselective Synthesis of β-Amino Esters by the Lewis Acid-Mediated Reaction of N-Tosyl Aldimines with Ketane Bis(trimethylsilyl) Acetals
- Guidelines for Diagnosis and Management of Cardiovascular Sequelae in Kawasaki Disease (JCS 2008) : Digest Version
- Development of Soft-Based Double-Stranded Peptide Chelators which Selectively Separate Europium and Lanthanum Ions Based on the Hardness Concept(Communications to the Editor)
- Development of Functional Double-stranded Peptide Chelators Which Selectively Separate Europium and Lanthanum Ions
- Multiple fungal splenic abscesses in a patient with T-acute lymphoblastic leukemia undergoing chemotherapy
- Colonic Tattooing Using Fluorescence Imaging with Light-Emitting Diode-Activated Indocyanine Green : A Feasibility Study
- Magic Numbers in a Mass Spectrum of Lithium Clusters Emitted from a Liquid Metal Ion Source
- Magic Numbers and Critical sizes of Tin Clusters Emitted from a Liquid Metal Ion Source
- A Role of Occlusion in the Etiology of TMD
- Morphology and Molecular Phylogeny of Chara altaica (Charales, Charophyceae), a Monoecious Species of the Section Desvauxia
- Soft X-Ray Absorption Spectra of Silver Chloride and Thallous Chloride
- Health-related quality of life in patients with advanced colorectal cancer : results from a phase II study of S-1 combined with irinotecan (CPT-11)
- Study of Oral Health Care and Stomatognathic Function in the Elderly
- Temporomandibular disorders associated with a mandibular functional shift by scissors-bite : a case report
- ASEPTIC ENDOSCOPY : APPLICATION OF NEWLY DEVELOPED ENDOSCOPE WASHER SYSTEM
- Effectiveness of Occlusal Treatment Based on Occlusal Examination Utilizing EMG Biofeedback for Temporomandibular Disorders
- Effects of Demethylallosamidin, a Potent Yeast Chitinase Inhibitor, on the Cell Division of Yeast(Biological Chemistry)
- Health-related quality of life of colorectal cancer patients receiving oral UFT plus leucovorin compared with those with surgery alone
- Social Class Inequalities in Self-rated Health and Their Gender and Age Group Differences in Japan
- Simultaneous Elevation of Serum Amylase and Lipase Levels Due to Multiclass Immunoglobulin-Bound Enzymes in a Patient with Alcoholic Liver Cirrhosis
- Scanning Electron Microscopic Observation of Pancreatic Ducts in WBN/Kob Rats
- Preparation of Ammonium Polyphosphate Form II from the System of Ammonium Orthophosphate-Urea
- The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort : the Suita Study
- Standard method for ultrasound imaging of coronary artery in children