キノアタンパク質のCaco-2細胞における胆汁酸吸収抑制作用

概要

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It has been reported that quinoa protein suppresses the rise of cholesterol levels in serum and in liver. Therefore the authors examined the effect of bile acid absorption by quinoa protein in human intestinal epithelial cell line Caco-2 to which different amounts of quinoa protein (Qpro Omg, 10mg, 100mg) were added with the fixed amount of bile acid. Both the 10mg and 100mg Qpro groups did not show any difference in the inhibition of bile acid absorption in the Caco-2 after 120 minutes, but after 240min., the bile acid showed 54% decrease in 10mg Qpro group and 72% decrease in the 100mg Qpro group. The authors suggest that one of the suppression mechanisms of cholesterol levels by quinoa protein in serum and in liver is that the quinoa protein suppresses the formation of cholesterol micelles hence causing the inhibition of both cholesterol and bile acid absorption and re-absorption from intestinal epithelium.
2006-12-01