Effects of Ganoderma lucidum Polysaccharide on CYP2E1, CYP1A2 and CYP3A Activities in BCG-Immune Hepatic Injury in Rats(Pharmacology)
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概要
- 論文の詳細を見る
The purpose of the present study was to investigate the effect of Ganoderma lucidum polysaccharide (GLPS), a major active component in Chinese medicinal fungus, on cytochrome P450 metabolic activity in Bacillus Calmette Guerin (BCG)-induced immune hepatic injury in rats. The enzyme kinetics of the probes including chlorzoxazone (CYP2E1), phenacetin (CYP1A2) and nifedipine (CYP3A) were evaluated by HPLC. The results showed that BCG-pretreatment (125 mg/kg) significantly increased serum levels of alanine transaminase (ALT), nitrite and malondialdehyde (MDA), inhibited activities of superoxide dismutase (SOD) and decreased P450 total content in microsomes (p<0.05). Administration of GLPS (50 and 200 mg/kg) reversed above hepatic injury stimulated by BCG in vivo. Moreover, GLPS dose-dependently inhibited activities of CYP2E1, CYP1A2 and CYP3A in hepatic microsomes in vitro, suggesting that inhibition of GLPS on P450 oxidative metabolism might participate in the hepatoprotective mechanism, and also suggested that pharmacokinetics might be changed by drug-herb interaction.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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WANG Xin
Department of Electrical Engineering, Aichi Institute of Technology
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Zhang Guo-liang
Department Of Pharmacology Basic Medical School Beijing University
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Li Dan
Department Of Pharmacology Basic Medical School Beijing (peking) University
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ZHAO Xuan
Department of Pharmacology, Basic Medical School, Beijing (Peking) University
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LOU Ya-Qing
Department of Pharmacology, Basic Medical School, Beijing (Peking) University
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LIN Zhi-Bin
Department of Pharmacology, Basic Medical School, Beijing (Peking) University
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Wang Xin
Department Of Electrical Engineering Aichi Institute Of Technology
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Lin Zhi-bin
Department Of Pharmacology Basic Medical School Beijing (peking) University
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Zhao Xuan
Department Of Pharmacology Basic Medical School Beijing (peking) University
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Zhang Guo-liang
Department Of Pharmacology Basic Medical School Beijing (peking) University
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Lou Ya-qing
Department Of Pharmacology Basic Medical School Beijing (peking) University
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Wang Xin
Department Of Advanced Systems Control Engineering Graduate School Of Science And Engineering Saga U
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Wang Xin
Department Of Pharmacology Basic Medical School Beijing (peking) University
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Li Dan
Department Of Hygiene And Preventive Medicine Hokkaido University School Of Medicine
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