Polysaccharide Extract Isolated From Ganoderma lucidum Protects Rat Cerebral Cortical Neurons From Hypoxia/Reoxygenation Injury

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概要

• 論文の詳細を見る

• The effect of polysaccharide extract isolated from Ganoderma lucidum (Gl-PS) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. Gl-PS (1, 10, 100 μg/ml) increased neuron viability following H/R as measured by the inhibition of MTT reduction. Gl-PS also significantly reduced malondialdehyde content and reactive oxygen species production and increased the manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B induced by H/R was blocked. These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury.

• 公益社団法人 日本薬理学会の論文

著者

• Lin Shu-qian

  Fuzhou Green Valley Institute Of Bio-pharmaceutical Technology

• Lin Zhi-bin

  Department Of Pharmacology Basic Medical School Beijing (peking) University

• Liu Ji-hong

  Confocal Microscope Laboratory Peking University Health Science Center

• Zhao Hong-bo

  Department Of Pharmacology School Of Basic Medical Sciences Peking University Health Science Center

• Lin Zhi-Bin

  Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center

関連論文

• Effects of Ganoderma lucidum Polysaccharide on CYP2E1, CYP1A2 and CYP3A Activities in BCG-Immune Hepatic Injury in Rats(Pharmacology)
• Cellular and Molecular Mechanisms of Immuno-modulation by Ganoderma lucidum
• Polysaccharide Extract Isolated From Ganoderma lucidum Protects Rat Cerebral Cortical Neurons From Hypoxia/Reoxygenation Injury
• Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley
• Polysaccharide Extract Isolated From Ganoderma lucidum Protects Rat Cerebral Cortical Neurons From Hypoxia/Reoxygenation Injury

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