Suppressing Effect of Tannic Acid on UV and Chemically Induced Chromosome Aberrations in Cultured Mammalian Cells(Biological Chemistry)
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概要
- 論文の詳細を見る
UV-induced structural chromosome aberrations were suppressed by post-treatment with tannic acid (m-galoyl gallic acid) in cultured Chinese hamster ovary cells. A significant decrease in the frequencies of chromosome aberrations in the presence of tannic acid was observed in cells treated with mitoycin C or methylmethanesulfonate but not with X-rays of bleomycin. The effects of tannic acid were dependent on the DNA pre-replicational G1 phase of the cell cycle. Furthermore, tannic acid enhanced the liquid-holding effect on UV-irradiated cells at G1 phase. On the other hand, the number of surviving UV-irradiated cells increased in the presence of tannic acid. These results suggest the possibility of promotion by tannic acid of an excision repair system of mammalian cells.
- 社団法人日本農芸化学会の論文
- 1988-10-23
著者
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SHIRASU Yasuhiko
Institute of Environmental Toxicology
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Sakai Yu
Institute Of Environmental Toxicology
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Matsumoto Kyomu
Institute Of Environmental Toxicology
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Ohta Toshihiro
Institute Of Environmental Toxicology
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IMANISHI Hisako
Institute of Environmental Toxicology
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WATANABE Mie
Institute of Environmental Toxicology
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