Synthesis and Biological Activities of N-Acetylglucosaminyl-β(1→4)-N-Acetylmuramyl Tri- and Tetrapeptide Derivatives(Organic Chemistry)
スポンサーリンク
概要
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The acylated, amidated and esterified derivatives of N-acetylglucosaminyl-β(1→4)-N-acetylmuramyl tri- and tetrapeptide were synthesized and examined as to their protective effect on pseudomonal infection in the mouse and pyrogenicity in the rabbit. Modifications of the terminal end function of the peptide moieties in their molecules caused enhancement of resistance to pseudomonal infection and reduction of pyrogenicity. Among the compounds tested, sodium N-acetylglucosarninyl-β(1→4)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl-(L)-stearoyl-(D)-meso-2,6-diaminopimelic acid-(D)-amide and sodium N-acetylglucosaminyl-β(1→4)-N-acetylmuramyl-L-alanyl-D-isoglutaminyl-(L)-stearoyl-(D)-meso-2,6-diaminopimelic acid-(D)-amide-(L)-D-alanine were found to be advantageous and conceivably worthwhile for further investigation as immunobiologically active compounds.
- 社団法人日本農芸化学会の論文
- 1986-10-23
著者
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Naruto Shunsuke
Research Laboratories Dainippon Parmaceutical Co. Ltd.
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Kawata Shigeo
Research Information Center Institute Of Plasma Pysics Nagoya University
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Kawata Shigeo
Research Information Center Institute Of Plasma Physics Nagoya University:department Of Energy Scien
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Naruto Shunsuke
Research And Development Division Dainippon Pharmaceutical Co. Ltd.
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FURUTA Rhyuji
Research Laboratories, Dainippon Parmaceutical Co., Ltd.
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MINAMI Akira
Research Laboratories, Dainippon Parmaceutical Co., Ltd.
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KOTANI Shozo
Department of Microbiology and Oral Microbiology, Osaka University Dental School
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Minami Akira
Research Laboratories Dainippon Parmaceutical Co. Ltd.
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Kotani S
Department Of Microbiology And Oral Microbiology Osaka University Dental School
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Furuta R
Research Laboratories Dainippon Parmaceutical Co. Ltd.
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Kawata Shigeo
Research Laboratories Dainippon Parmaceutical Co. Ltd.
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Kawata Shigeo
Research Information Center Institute Of Plasma Physics Nagoya University
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