Preparation of 1,6-Dihydro-3-benzazocines and Related Compounds by Base-Induced Intramolecular Cyclization of 1,2-Bis(2-isocyano-2-tosylethyl)benzene(Organic,Chemical)
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概要
- 論文の詳細を見る
Treatment of 1,2-bis(2-isocyano-2-tosylethyI)benzene (5a) with potassium hydroxide in methanol, ethanol, or isopropyl alcohol afforded 2-substituted 1,6-dihydro-5-isocyano-3-benzazocines (15a-c) by intramolecular cyclization. When tert-butyl alcohol was used as a solvent under the same conditions, 5a was led to 3,6-dihydro-5-isocyano-3-benzazocin-2(1H)-one (18) instead of the corresponding benzazocine of type 15d. N-Alkylation of 18 with methyl, ethyl, and isopropyl iodides yielded 3-alkylated 3,6-dihydro-5-isocyano-3-benzazocin-2(1H)-ones (20a-c), which are structural isomers of 15a-c.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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SASAKI Hideaki
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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KITAGAWA Tokujiro
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Sasaki H
Kobe Gakuin Univ. Kobe Jpn
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Kitagawa Tokujiro
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Sasaki Hideaki
Faculty Of Pharmaceutical Science Kobe Gakuin University
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