Cyclophanes. VIII. Synthesis and DNA-Cleaving Activities of Novel Heterocyclophanes Containing Two 4,4'-Bithiazole Rings

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概要

• 論文の詳細を見る

• The novel heterocyclophanes, 3,6,21,24-tetraaza[8.8](2,2')(4,4'-bithiazolophane) (3a) and 3,7,22,26-tetraaza-[9.9](2,2')(4,4'-bithiazolophane) (3b) were readily synthesized by the cyclization of 1,4-dibromobutane-2,3-dione with N, N'-bis(tert-butoxycarbonyl)ethylenediamine-N, N'-dipropionthioamide and N, N'-bis(tert-butoxycarbonyl)-trimethylenediamine-N, N'-dipropionthioamide, respectively, followed by acidic deprotection. Under physiological conditions, 3a and 3b at 5 μM showed considerable DNA-cleaving activities in the presence of Co(II) without any reducing agent.

• 公益社団法人日本薬学会の論文
• 1997-01-15

著者

• Nakamoto Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University Ikawadani

• Nakamoto Yasuyuki

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Sasaki Hideaki

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Sasaki Hideaki

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University Ikawadani

• SUEHIRO Atsumi

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University Ikawadani

• Suehiro Atsumi

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University Ikawadani

関連論文

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• Cyclophanes. VIII. Synthesis and DNA-Cleaving Activities of Novel Heterocyclophanes Containing Two 4,4'-Bithiazole Rings
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