Preparation and Root Growth-Inhibitory Activity of N-Substituted 2-(2-Chloroacetamido)-3-(furan-2-yl) propanamides
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概要
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A series of N-substituted 2-(2-chloroacetamido)-3-(furan-2-yl) propanamides (16-18) was prepared through the reaction of chloroacetyl chloride with N-substituted 2-amino-3-(furan-2-yl) propanamides (15), which were obtained via condensation of 2-(tert-butoxycarbonylamido)-3-(furan-2-yl)propanoic acid (Boc-furylalanine) (8) with amines (9, 11, 13), followed by hydrolysis of the resultant N-substituted Boc-furylalanine acid amides (10, 12, 14) in the presence of HCI/dioxane. The biological activity of the prepared 16, 17 and 18 as root growth inhibitors was examined by germination assay using rape seed. At the concentration of 5.0×10^<-5>M, the most active compound, 2-(2-chloroacetamido)-N-(2, 6-diethylphenyl)-3-(furan-2-yl)propanamide (16n), showed potent root growth-inhibitory activity of 76% towards rape seedlings.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Asada Makoto
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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KITAGAWA Tokujiro
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kitagawa Tokujiro
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
関連論文
- Improved Preparation of Racemic 2-Amino-3-(heteroaryl)propanoic Acids and Related Compounds Containing a Furan or Thiophene Nucleus
- Preparation and Root Growth-Inhibitory Activity of N-Substituted 2-(2-Chloroacetamido)-3-(furan-2-yl) propanamides
- Synthesis and Root Growth-Inhibitory Activity of 2- and 3-(Haloacetylamino)-3-(2-furyl)propanoic Acids
- Preparation of N'-[2-(5,6-Dimethylbenzothiazolyl)]-N-furfuryloxamide with Plant Growth Regulatory Activity
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- Preparation and Plant Growth-Regulatory Activity of N'-Chloro-Substituted Phenyl- and Benzyl-N-furfuryloxamides
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