常圧低酸素環境への暴露および自発的運動がラット血液性状に及ぼす影響

概要

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The purpose of the present study was to examine the effects of moderate normobaric hypoxia and voluntary exercise training under the condition for 50 days on haematological properties in rats. Twenty-eight male Wistar rats (8-week old) were randomly assigned to one of 4 groups; 1) normoxic sedentary(NS, n=8), 2) normoxic trained (NT, n=6), 3) hypoxic sedentary (HS, n=8), and 4) hypoxic trained (HT, n=6) group. The hypoxic (HS and HT) groups were housed under a normobaric hypoxic condition (15.4%O_2). The trained (NT and HT) groups were kept within cages with a running wheel and running distance was measured everyday. The blood sample was analyzed at the end of experimental period. The daily running distance was greatly depressed by the hypoxic condition. Red blood cell, hemoglobin, and hematocrit were significantly increased by the hypoxic condition but these parameters were not effected by the voluntary running training. Mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were slightly increased by the both conditions. It was suggested that not voluntary running training but moderate normobaric hypoxic condition could cause erythropoiesis in rats.