Acute Effects of Fast Neutron Irradiation on Mouse Liver
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概要
- 論文の詳細を見る
Until now, the multiple biological effects of ionizing radiation on liver have been reported. However, there has not been any reports of fast neutron-mediated liver injuries including liver regeneration or fibrosis. Here, we described the biological effects of acute fast neutron irradiation on the liver. After the fast neutron irradiation of 0, 0.25, 1, 2, 4 and 8 Gy on mice, hepatocyte necrosis and a decrease in the total number of hepatocytes were induced dose-dependently. Binucleated hepatocytes and PCNA positive hepatocytes increased significantly at 0.25 and 1 Gy, but decreased markedly at 2, 4 and 8 Gy. The expression of cytochrome P450 2E1 (CYP2E1) showed a dose-dependent increase after fast neutron irradiation. The activation of p-Smad2/3, signaling intermediates of transforming growth factor-beta (TGF-β), increased in hepatocytes after exposure of 0.25, 1, and 2 Gy of fast neutrons, but it was not detected in hepatic stellate cells (HSCs). In conclusion, fast neutron-induced liver damages, likely loss of hepatocytes, necrotic foci and vacuolar changes, were note on the dose dependent manner and hepatocellular regeneration were significantly diminished at doses of 2, 4 and 8Gy in a dose-dependent manner. These alterations may at least in part be associated with dose-dependent increase in CYP2E1 and p-Smad2/3. These results show promise as an approach for the treatment of fast neutrons on liver tumors and in the study of pathogenesis regarding the fast neutron-irradiated damages of the liver.
- 日本放射線影響学会の論文
- 2007-05-15
著者
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Kwak Dong-mi
Department Of Pathology College Of Veterinary Medicine Kyungpook National University
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Jeong Da-hee
Department Of Pathology College Of Veterinary Medicine Kyungpook National University
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Jeong Da
Department Of Veterinary Pathology College Of Veterinary Medicine
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Lee S‐k
Department Of Pathology Korea Institute Of Radiological & Medical Sciences
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Lee Seung-sook
Department Of Pathology Korea Cancer Center Hospital
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Lee Seung-sook
Department Of Anatomic Pathology Korea Cancer Center Hospital
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Kim Soon-bok
Department Of Pathology College Of Veterinary Medicine Gyeongsang National University
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JEONG Kyu-Shik
Korea Research Institute of Bioscience and Biotechnology
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HONG Il-Hwa
Department of Pathology, College of Veterinary Medicine, Kyungpook National University
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KI Mi-Ran
Department of Pathology, College of Veterinary Medicine, Kyungpook National University
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DO Sun-Hee
Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University
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JEONG Kyu-Shik
Department of Pathology, College of Veterinary Medicine, Kyungpook National University
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KIM Tae-Hwan
Department of Pathology, College of Veterinary Medicine, Kyungpook National University
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Kim Tae-hwan
韓国
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Do Sun-hee
Department Of Clinical Pathology College Of Veterinary Medicine Konkuk University
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Do Sun
Department Of Veterinary Pathology College Of Veterinary Medicine
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Jee Young-heun
Department Of Veterinary Medicine And Applied Radiological Science Institute Cheju National Universi
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Lee Seung-sook
Department Of Pathology Korea Institute Of Radiological & Medical Sciences
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Jeong Won-il
Department Of Pathology College Of Veterinary Medicine Kyungpook National University
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Jeong Won
Department Of Veterinary Pathology College Of Veterinary Medicine
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Ki Mi-ran
韓国
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Kim Tae-hwan
Department Of Anatomy College Of Veterinary Medicine Chungnam National University
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Jeong Kyu-shik
Department Of Pathology College Of Veterinary Medicine Kyungpook National University
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Jeong Kyu
Department Of Veterinary Pathology College Of Veterinary Medicine
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