Effectiveness of Extracted-teeth as Bone Substitute : Application to Parietal Bone Defects in Rabbits

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概要

• 論文の詳細を見る

• Objectives: Bone substitute comparable to autologous bone has been clinically desired. The purpose of the present study was to examine effects of demineralized dentin matrix (DDM) on regeneration in surgical bone defect. Material and Methods: Rabbit upper right incisors were extracted and demineralized and then, dentin slices in 8μm thickness (DDM) were prepared. Two surgical bone defects were created on the skull of each rabbit. Autologous DDM was mixed with autologous platelete-rich plasma (PRP) and applied to the bone defect (experimental site) whereas autologous PRP was applied to another bone defect (control site). To keep the space of the bone regeneration, each bone defect was covered with two methylcellulose membranes. The rabbits were sacrificed 4 weeks and 8 weeks after the surgery. Subsequently, radiographical and histomorphometrical analyses were performed. Results: In the soft X-ray photographs the experimental site was more radiopaque than the control site at 4 and 8 weeks. Similarly, bone mineral density of the experimental site was higher at both time points. Histologically, bone formation was induced along with DDM and newly-formed bone in the experimental site was extensive and matured, compared to the control site. Histomorphometrically, at 4 weeks, bone volume and the parameters of bone formation and resorption of the experimental site were higher than the ones of the control site. Conclusion: The present results indicate that DDM is effective as a bone substitute accelerating bone repair.

• 日本再生歯科医学会の論文
• 2005-09-30

著者

• Tint Kyaw

  Oral Implantology And Regenerative Dental Medicine Tokyo Medical & Dental University

• Ohya K

  Section Of Pharmacology Department Of Hard Tissue Engineering Graduate School Tokyo Medical And Dent

• Ohya K

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Ohya Keiichi

  Pharmacology Department Of Hard Tissue Engineering Graduate School Tokyo Medical And Dental Universi

• Ohya Keiichi

  Pharmacology Department Of Hard Tissue Engineering Graduate School Tokyo Medical And Dental Universi

• Ohya K

  Tokyo Medical And Dental Univ.

• Aoki K

  Section Of Pharmacology Department Of Hard Tissue Engineering Graduate School Tokyo Medical And Dent

• Aoki Kazuhiro

  Pharmacology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental Unive

• Ohya Keiichi

  Department Of Hard Tissue Engineering Section Of Pharmacology Tokyo Medical And Dental University Gr

• Kuroda Shinji

  Section Of Oral Implantology And Regenerative Dental Medicine Department Of Masticatory Function Reh

• Kasugai S

  Section Of Oral Implantology And Regenerative Dental Medicine Department Of Masticatory Function Reh

• Kasugai Shohei

  Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University

• Kasugai Shohei

  Oral Implantology And Regenerative Dental Medicine

• KURODA Shinji

  Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitatio

• Kondo Hisatomo

  Section Of Oral Implantology And Regenerative Dental Medicine Department Of Masticatory Function Reh

• Ohya Keiichi

  Pharmacology Department Of Hard Tissue Engineering Division Of Bio-matrix Graduate School Tokyo Medi

• KONDO Hisatomo

  Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University

• FUJIMORI Tatsuya

  Oral Implantology and Regenerative Dental Medicine, Tokyo Medical & Dental University

• Fujimori Tatsuya

  Oral Implantology And Regenerative Dental Medicine

• Fujimori Tatsuya

  Oral Implantology And Regenerative Dental Medicine Tokyo Medical & Dental University

• Aoki Kazuhiro

  Pharmacology Department Of Hard Tissue Engineering Graduate School Tokyo Medical And Dental Universi

• Kasugai S

  Section Of Oral Implantology And Regenerative Dental Medicine Department Of Masticatory Function Reh

• Aoki Kazuhiro

  Pharmacology Department Of Hard Tissue Engineering Division Of Bio-matrix Graduate School Tokyo Medi

• Aoki Kazuhiro

  Pharmacology Department Of Hard Tissue Engineering Tokyo Medical & Dental University

• KURODA Shinji

  Oral Implantology and Regenerative Dental Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

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