Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect
スポンサーリンク
概要
- 論文の詳細を見る
Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response.
- 社団法人 日本薬理学会の論文
- 2007-08-20
著者
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Kasugai Shohei
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Kasugai Shohei
Oral Implantology And Regenerative Dental Medicine
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SATO Daisuke
Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitatio
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NYAN Myat
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
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ODA Mitsumasa
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
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MACHIDA Tetsu
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
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KOBAYASHI Hiroshi
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
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NAKAMURA Takahiro
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University
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Sato Daisuke
Oral Implantology And Regenerative Dental Medicine Department Of Masticatory Function Rehabilitation
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Nyan Myat
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Nakamura Takahiro
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Sato Daisuke
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Machida Tetsu
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Oda Mitsumasa
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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Kobayashi Hiroshi
Oral Implantology And Regenerative Dental Medicine Tokyo Medical And Dental University
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