The Induction of Hepatic Cytochrome P4501A Subfamily Enzymes by Nitroanisidines : Species Difference among Experimental Rodents

スポンサーリンク

概要

• 論文の詳細を見る

• Species differences in the induction of hepatic cytochrome P4501A (CYP1A) subfamily enzymes by nitroanisidines, such as 2-methoxy-4-nitroaniline (2-MeO-4-NA), 2-methoxy-5-nitroaniline (2-MeO-5-NA), and 4-methoxy-2-nitroaniline (4-MeO-2-NA), were investigated among male F344 rats, C57BL/6 Cr mice, and Hartley guinea pigs. All species of animals were treated with a single intraperitoneal injection of each chemical (0.44 mmol/kg body weight), and changes in hepatic microsomal activities for methoxyresorufin O-demethylation (MROD) and ethoxyresorufin O-deethylation (EROD), which were mainly catalyzed by CYP1A2 and CYP1A1, respectively, were examined. Gene expression levels of hepatic CYP1A subfamily enzymes were also examined by a reverse transcription-polymerase chain reaction (RT-PCR) method. These results indicated that all the chemicals examined showed abilities to induce hepatic CYP1A subfamily enzymes in rats but not in the other examined animal species. In the rat liver, the abilities of the chemicals to induce microsomal MROD activity and CYP1A2 gene expression were in the order 2-MeO-4-NA > 2-MeO-5-NA > 4-MeO-2-NA, whereas their abilities to induce microsomal EROD activity and CYP1A1 gene expression were in the order 4-MeO-2-NA > 2-MeO-5-NA > 2-MeO-4-NA. These findings demonstrate for the first time that there are species differences in the induction of hepatic CYP1A subfamily enzymes by the nitroanisidine isomers among rats and other rodents, mice, and guinea pigs.

• 公益社団法人日本薬学会の論文
• 2006-08-01

著者

• DEGAWA Masakuni

  Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka

• Souma Shinji

  Department Of Molecular Toxicology And Coe Program In The 21st Century School Of Pharmaceutical Scie

• SEKIMOTO Masashi

  Department of Molecular Toxicology and COE Program in the 21st Century, School of Pharmaceutical Sci

• Sato M

  Section Of Genetic Engineering Research Center For Genetic Engineering And Cell Transplantation Toka

• Sekimoto Masashi

  Department Of Molecular Toxicology And Global Coe Program School Of Pharmaceutical Sciences Universi

• Degawa M

  Department Of Molecular Toxicology And Global Coe Program School Of Pharmaceutical Sciences Universi

• Degawa Masakuni

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Degawa Masakuni

  Department Of Molecular Toxicology And Global Coe Program School Of Pharmaceutical Sciences Universi

• Degawa Masakuni

  Dep. Of Molecular Toxicology And Global Center Of Excellence Program School Of Pharmaceutical Scienc

関連論文

• The Effects of D-galactosamine- or Carbon Tetrachloride-Induced Regeneration on Induction of Rat Liver Cell Foci in a Model for Detection of Initiation Activities of Chemicals
• Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine
• Decreased Levels of 2-Amino-3-methylimidazo[4,5-f]quinoline-DNA Adducts in Rats Treated with β-Carotene, α-Tocopherol and Freeze-dried Aloe
• The gene expression of hepatic proteins responsible for DNA repair and cell proliferation in tamoxifen-induced hepatocarcinogenesis
• No Involvement of the Nerve Growth Factor Gene Locus in Hypertension in Spontaneously Hypertensive Rats
• A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice
• The interface between innate and acpuired immunity: glycolipid antigen presentation by CD1 d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes
• Functional heterogeneity among bone marrow-derived dendritic cells conditioned by T_h1-and T_h2-biasing cytokines for the generation of allogeneic cytotoxic T lymphocytes
• Natural Killer T Cell Ligand α-Galactosylceramide Inhibited Lymph Node Metastasis of Highly Metastatic melanoma Cells
• Effects of Lead Nitrate on Liver Weight and Serum Total Cholesterol Amounts in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats
• SUSCEPTIBILITY OF ANIMALS TO HEPATOCARCINOGENIC AROMATIC AMINES CORRELATES WITH THE INDUCTION OF THE CARCINOGEN ACTIVATION ENZYME (S) WITH THE AMINES
• O11-10 Changes in the expression of the genes related to chemical carcinogenesis during tamoxifen-induced hepatocarcinogenesis in rats
• DNA damage and altered gene expression of enzymes for metabolism and DNA repair by tamoxifen and toremifene in the female rat liver
• Increased Expression of Cyclin-Dependent Kinase-Interacting Protein p21 during Tamoxifen-Induced Hepatocarcinogenesis in Female Rats
• Dysfunction of Paracellin-1 by Dephosphorylation in Dahl Salt-Sensitive Hypertensive Rats
• INDUCTION OF HEPATIC CYTOCHROME P450 ISOFORMS BY NICARDIPINE AT THERAPEUTIC DOSES IN SPONTANEOUSLY HYPERTENSIVE RATS
• The Induction of Hepatic Cytochrome P4501A Subfamily Enzymes by Nitroanisidines : Species Difference among Experimental Rodents
• Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
• Establishment of a Human Hepatoma Cell Line HepG2-A10 for a Reporter Gene Assay of Arylhydrocarbon Receptor Activators
• Establishment of a Rat Hepatic Cell Line, KanR2-XL8, for a Reporter Gene Assay of Aryl Hydrocarbon Receptor Ligands
• Gender-Related Differences in the Level of Serum Lipids in Meishan Pigs
• Constitutive Expression of Cytochrome P450 Genes in Newly Established Rat Hepatic Cell Lines
• Decreased Gene Expression of Testicular Cell-Specific Proteins in Cadmium-Induced Acute Testicular Toxicity
• Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats
• Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver
• Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
• Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
• ALTERATION OF HEPATIC CYTOCHROME P-450 ISOZYMES DURING HEPATOCARCINOGENESIS PROCESS IN RATS
• Altered Expression of Hepatic CYP1A Enzymes in Rat Hepatocarcinogenesis
• Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead-nitrate administration : strain-difference in the gene expression patterns
• Oxidative DNA Damage Induced by an N-Hydroxy Metabolite of Carcinogenic 4-Dimethylaminoazobenzene
• Gene Activations of CYP2B1 and CYP3A1 by Dihydropyridine Calcium Channel Antagonists in the Rat Liver : the Structure-Activity Relationship(Biochemistry/Molecular Biology)
• Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats
• Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats
• Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats
• Inhibitory Effects of Citrus Polymethoxyflavones, Nobiletin and its Analogues, on Acetylcholinesterase Activity
• 9-Methyl-7-bromoeudistomin D, a Caffeine Like Ca^ Releaser, Probably Binds to Cytochromes P450 1A1 and 2B in Liver Microsomes
• Establishment of a Stable Human Cell Line, HPL-A3, for Use in Reporter Gene Assays of Cytochrome P450 3A Inducers
• Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice
• Comparison of constitutive gene expression levels of hepatic cholesterol biosynthetic enzymes between Wistar-Kyoto and stroke-prone spontaneously hypertensive rats
• Induced expression of hepatic N-methyl-D-aspartate receptor 2C subunit gene during liver enlargement induced by lead nitrate, a hepatocellular mitogen
• Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin
• Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver

もっと見る 閉じる

スポンサーリンク