Formation of DNA Damaging Product from Light-Irradiated Nonylphenol

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概要

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• Nonylphenol (NP) is widely distributed in the environment as a microbial metabolite of nonylphenol polyethoxylates, which are commercially important surfactants. Although there are concerns regarding the estrogenic activity of NP and its effects on wildlife, this paper reports a new detrimental effect for NP; oxidative DNA damage. After UV or sunlight irradiation, several NP photoproducts were detected by high performance liquid chromatography (HPLC). Two HPLC fractions induced formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in calf thymus DNA. Based on gas chromatography/mass spectrometry and UV/visible spectrometry, one fraction was confirmed to contain 4-nonylcatechol. The other active compound remains unidentified. Non-irradiated NP did not exhibit any detectable 8-oxodG formation. These results suggest that NP induces oxidative DNA damage following environmental light exposure. This DNA damaging activity is a new adverse effect of NP and, in addition to estrogenic activity, should be investigated further and taken into consideration during NP risk assessment.

• 公益社団法人日本薬学会の論文
• 2006-02-01

著者

• Ueda Koji

  Faculty of Pharmacy, Meijo University

• Okamoto Yoshinori

  Faculty of Pharmacy, Meijo University

• Kojima Nakao

  Faculty of Pharmacy, Meijo University

• Hayashi Tomohiro

  Faculty Of Pharmacy Meijo University

• Toda Chitose

  Faculty of Pharmacy, Meijo University

• Toda Chitose

  Faculty Of Pharmacy Meijo University

• Kojima Nakao

  Exploratory Medicinal Sciences Pfizer Global Research And Development(pgrd)-nagoya Laboratories Pfiz

• Kojima Nakao

  Faculty Of Pharmacy Meijo University

• Kojima Nakao

  Central Research Division Pfizer Pharmaceuticals Inc.

• Matsunami Shinpei

  Faculty of Pharmacy, Meijo University

• Kawanishi Shosuke

  Department of Environmental and Molecular Medicine, Mie University School of Medicine

• Matsunami Shinpei

  Faculty Of Pharmacy Meijo University

• Kawanishi Shosuke

  Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine

• Okamoto Yoshinori

  Fac. Of Pharmacy Meijo Univ.

• Toda Chitose

  The Research Institute Of Environmental Medicine Nagoya University

• UEDA Koji

  Faculty of Agriculture, Yamagata University

• Kojima Nakao

  Faculty of Pharmaceutical Sciences, Kyoto University

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