Oxidative DNA Damage in Relation to Neurotoxicity in the Brain of Mice Exposed to Arsenic at Environmentally Relevant Levels
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概要
- 論文の詳細を見る
To clarify the association between oxidative DNA damage and the neurotoxicity of arsenic, the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an index of oxidative DNA damage in the brain was examined in mice fed with drinking water containing 1 or 2 ppm arsenic, using an HPLC-electrochemical detector and immunohistochemical method. 8-OHdG levels were significantly increased in the brain of mice given arsenic and its immunoreactivity was distributed in the cerebral and cerebellar cortexes. Cerebral cortex neurons and Purkinje cells in the cerebellar cortex showed degenerative changes in accordance with the distribution of 8-OHdG immunoreactivity. The levels of arsenic in this study were lower than those reported in epidemiological studies. Thus, we conclude that environmentally relevant levels of arsenic induce pathological changes through oxidative DNA damage in the brain tissues in vivo and that cerebral and cerebellar cortex neurons seem to be the major targets of arsenic neurotoxicity.
- 社団法人日本産業衛生学会の論文
- 2005-09-00
著者
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Ma Ning
The Second Department Of Anatomy School Of Medicine Mie University
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Murata Mariko
Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine
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Zhong Laifu
Department Of Toxicology Dalian Medical University
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Yamauchi Toru
Department Of Neurosurgery Hokkaido University School Of Medicine
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Oikawa Shinji
Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine
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Piao Fengyuan
Department Of Occupational And Environmental Health Dalian Medical University
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Hiraku Yusuke
Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine
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Kawanishi Shosuke
Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine
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Yokoyama Kazuhito
Department Of Chemistry Faculty Of Education Gifu University
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YAMAUCHI Toru
Department of Public Health and Occupational Medicine, Graduate School of Medicine, Mie University
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CHENG Fanyin
Department of Health administration, Dalian Medical University
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KAWANISHI Shosuke
Department of Environmental and Molecular Medicine, Graduate School of Medicine, Mie University
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MA Ning
The Second Department of Anatomy, Graduate School of Medicine, Mie University
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ZHONG Laifu
Department of Hygiene, Dalian Medical University
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YOKOYAMA Kazuhito
Department of Public Health and Occupational Medicine, Graduate School of Medicine, Mie University
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OIKAWA Shinji
Department of Environmental and Molecular Medicine, Graduate School of Medicine, Mie University
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PIAO Fengyuan
Department of Hygiene, Dalian Medical University
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HIRAKU Yusuke
Department of Environmental and Molecular Medicine, Graduate School of Medicine, Mie University
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