Effects of Prednisolone and Complex of Vitamin B_1, B_2, B_6 and B_<12> on Organophosphorus Compound-Induced Delayed Neurotoxicity

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概要

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• Protective effects of prednisolone as a synthetic adrenal cortical hormone and complex of vitamin B_1, B_2, B_6 and B_<12> on organophosphorus compound-induced delayed neurotoxicity (OPIDN) caused by leptophos and tri-ocresyl phosphate (TOCP) as organophosphates (OPs) were examined. Nine groups of hens (six for each) were used. Eight groups received intravenous injection of 30 mg/kg of leptophos or 40 mg/kg of TOCP (four groups in each). Among them, three groups which received leptophos were given (p.o.) predonisolone (2 mg/body), vitamin B complex (25 mg/body) or both 3 h after OPs injection and then every day for 15 d (one group for each); the same treatment was performed on three groups which received TOCP. The remaining one group served as controls. It was observed that delayed neuropathy induced by OPs could not be resisted completely by the treatment with prednisolone or vitamin B complex, but clinical signs of OPIDN and pathological changes in hens that received these two protective agents after OPs were less severe than those in hens that received only OPs. Of these groups, the improvement in clinical signs was best shown in hens that received the both two protective agents. In addition, improvement in clinical signs among the hens that did not deteriorate to paralysis was observed. In particular, those which developed mild ataxia recovered well. It is indicated that combining administration of prednisolone and vitamin B complex early before clinical signs are manifest is effective in alleviating neuropathy. It is also suggested that recovery or good prognosis will be expected, as long as progression of the clinical signs is prevented before paralysis develops in delayed neuropathy.

• 社団法人日本産業衛生学会の論文

著者

• Yamamoto Hidetaka

  Department Of Anatomic Pathology Graduate School Of Medical Sciences Kyushu University

• Ma Ning

  三重大学 医学部眼科学

• Ma Ning

  The Second Department Of Anatomy School Of Medicine Mie University

• YOKOYAMA Kazuhito

  Department of Epidemiology and Environmental Health, Juntendo University School of Medicine

• Yamamoto Hidetaka

  Department Of Forensic Medicine And Sciences School Of Medicine Mie University

• Yamamoto Hidetaka

  Department Of Anatomic Pathology Faculty Of Medicine Kyushu University

• PIAO Fengyuan

  Department of Occupational and Environmental Health, Dalian Medical University

• YAMAUCHI Toru

  Department of Public Health, School of Medicine, Mie University

• Yamauchi Toru

  Department Of Public Health School Of Medicine Mie University

• Yamauchi Toru

  Department Of Neurosurgery Hokkaido University School Of Medicine

• Piao Fengyuan

  Department Of Occupational And Environmental Health Dalian Medical University

• Piao Fengyuan

  Department Of Public Health School Of Medicine Mie University

• Yokoyama Kazuhito

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Yokoyama Kazuhito

  Department Of Chemistry Faculty Of Education Gifu University

• PIAO Fengyuan

  Department of Hygiene, Dalian Medical University

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