Development of a biocompatible painless microneedle by ion-sputtering deposition

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概要

• 論文の詳細を見る

• The purpose of this study is to fabricate and characterize a titanium alloy microneedle, which can be used in a bio-MEMS such as a HMS (health monitoring system) for blood-sugar-level measurement. As an important contribution to bio-MEMS technology, we fabricated a microneedle with an inner diameter of 100μm and an outer diameter of 200μm, which mimics the female mosquito's painless blood extraction mechanism. In this study, the microneedle was fabricated through (1) selection of a biocompatible material from titanium alloys by cytotoxic assay, (2) RF magnetron sputtering deposition to generate microtubes with an inner diameter of 100μm, an outer diameter of 200μm and a length of 4mm, and (3) evaluation of the microneedle extraction by vacuum blood-extraction tests. Consequently, the pure titanium and titanium alloy (Ti-15Mo-5Zr-3Al) microneedle deposited by RF magnetron sputtering achieved a flow rate of 6.2μl/sec.

• 東海大学の論文

著者

• Yamamoto Hidetaka

  Department Of Anatomic Pathology Graduate School Of Medical Sciences Kyushu University

• Yamamoto Hidetaka

  Department Of Mechanical Engineering Tohoku Gakuin University

• Yamamoto Hidetaka

  Department Of Anatomic Pathology Faculty Of Medicine Kyushu University

• TSUCHIYA Kazuyoshi

  Department of Precision Engineering, Tokai University

• JINNINN Satoshi

  Department of Mechanical Engineering, Osaka Institute of Technology

• UETSUJI Yasutomo

  Department of Mechanical Engineering, Osaka Institute of Technology

• NAKAMACHI Eiji

  Department of Mechanical Engineering, Osaka Institute of Technology

• Nakamachi Eiji

  Department Of Mechanical Engineering Osaka Institute Of Technology

• Jinninn Satoshi

  Department Of Mechanical Engineering Osaka Institute Of Technology

• Uetsuji Yasutomo

  Department Of Mechanical Engineering Osaka Institute Of Technology

• Tsuchiya Kazuyoshi

  Department Of Precision Engineering Tokai University

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