Mechanism of Oxidative DNA Damage Induced by Environmental Carcinogens and Antioxidants
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概要
- 論文の詳細を見る
Modification of DNA is believed to be a key step in mutagenesis and carcinogenesis. Reactive oxygen species(ROS) generated by environmental factors can cause oxidative DNA damage. This review focused on the role of oxidative DNA damage in mutagenesis and carcinogenesis mediated by environmental factors. This research investigated the mechanism of DNA damage induced by environmental chemicals and dietary factors using ^<32>P-labeled DNA fragments obtained from the c-Ha-RAS-1 protooncogene and the p16 and p53 tumor suppressor genes. In addition, the content of 8-oxo-7,8-dihydro-2'-deox-yguanosine(8-oxodG) was measured by using a high performance liquid chromatograph equipped with an electrochemical detector. 8-oxodG is probably one of the most abundant DNA lesion formed during oxidative stress. Antioxidants are considered as the most promising chemopreventive agents against various human cancers. However, some antioxidants play paradoxical roles acting as "double-edged sword". The present research also investigated the mechanism of DNA damage induced by antioxidants using human cultured cell lines and ^<32>P-labeled DNA fragments. This review shows recent experimental results and discusses the mechanisms of oxidative DNA damage in relation to carcinogenesis.
- 日本環境変異原学会の論文
- 2008-02-20
著者
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OIKAWA Shinji
Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth Science
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Oikawa Shinji
Department Of Environmental And Molecular Medicine Mie University Graduate School Of Medicine
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