Phthalate Esters Detected in Various Water Samples and Biodegradation of the Phthalates by Microbes Isolated from River Water
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概要
- 論文の詳細を見る
Phthalate esters(PEs), especially di-n-butyl phthalate(DBP)and di-(2-ethylhexyl)phthalate(DEHP)were detected in various water samples such as river water, well water and tap water. On degradation tests of PEs, Tempaku River water degraded almost 100% of diethyl phthalate(DEP), di-isobutyl phthalate and DBP, and approximately 70% of DEHP. All eight isolates from Tempaku River water(Rl-R7, D1)did not degrade dimethyl phthalate(DMP), but showed biodegradjng ability for the other PEs. The DBP-degrading ability was particularly high for the isolates R1-R3 and D1 of Acinetobacter lwoffii. Crude enzyme solunions prepared from bacterial cells of these isolates showed a higher degrading activiity for DEHP compared with that for microbiallydegradable DBP. Particularly high DEHP-degrading activity was found for crude enzyme solutions of the isolate D1. As metabolites from the river water and bacterial isolates, DMP and an unknown diester were produced from DEP. DMP, DEP, monomethyl phthalate, monobutyl phfhalate(MBP)and an unknown diester were produced from DBP. DBP, DEP, DMP and an unknown diester were produced from DEHP. As metabolites by the crude enzyme solutions, DMP, MBP and an unknown diester derivative were produced from DBP.DBP, mono-(2-ethylhexyl)phthalate and an unknown diester derivative were produced from DEHP. Diesters with shortened alkyl carbon chains were also found as metabolites by the isolates and their crude enzyme solutions. The results suggest that the alkyl chains in the diesters are also decomposed in addition to monoester formation from DBP or DEHP at the first step reported for animals and some types of bacteria.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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Kojima Nakao
Faculty of Pharmacy, Meijo University
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Hoshino K
The Research Institute Of Environmental Medicine Nagoya University
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Toda Chitose
Faculty of Pharmacy, Meijo University
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Toda Chitose
Faculty Of Pharmacy Meijo University
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Kojima Nakao
Exploratory Medicinal Sciences Pfizer Global Research And Development(pgrd)-nagoya Laboratories Pfiz
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Kojima Nakao
Faculty Of Pharmacy Meijo University
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Yasui Teruyo
Faculty Of Pharmacy Meijo University
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Nagano Hideo
Faculty Of Pharmacy Meijo University
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Kojima Nakao
Central Research Division Pfizer Pharmaceuticals Inc.
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Hashizume Kiyomatsu
Faculty of Pharmacy, Meijo University
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NANYA Jo
Faculty of Pharmacy, Meijo University
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Nanya Jo
Faculty Of Pharmacy Meijo University
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Hashizume Kiyomatsu
Faculty Of Pharmacy Meijo University
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Hoshino K
Univ. Tsukuba Tsukuba‐shi Jpn
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Toda Chitose
The Research Institute Of Environmental Medicine Nagoya University
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Kojima Nakao
Faculty of Pharmaceutical Sciences, Kyoto University
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